Evidence map›Paper›PMID 34692547›Full record

ArticleFrontiers in oncology2021

Radiomic Features of Multi-ROI and Multi-Phase MRI for the Prediction of Microvascular Invasion in Solitary Hepatocellular Carcinoma.

Yan Yang, WeiJie Fan, Tao Gu, Li Yu, HaiLing Chen, YangFan Lv, Huan Liu, GuangXian Wang, Dong Zhang

Abstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan YangDepartment of Radiology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
WeiJie FanDepartment of Radiology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
Tao GuDepartment of Radiology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
Li YuDepartment of Radiology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
HaiLing ChenDepartment of Pathology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
YangFan LvDepartment of Pathology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
Huan LiuGE Healthcare, Shanghai, China.
GuangXian WangDepartment of Radiology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.
Dong ZhangDepartment of Radiology, Second Affiliated XinQiao Hospital of Army Medical University, ChongQing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo develop and validate an MR radiomics-based nomogram to predict the presence of MVI in patients with solitary HCC and further evaluate the performance of predictors for MVI in subgroups (HCC ≤ 3 cm and > 3 cm). MATERIALS AND

methodsBetween May 2015 and October 2020, 201 patients with solitary HCC were analysed. Radiomic features were extracted from precontrast T

resultsHistopathological examinations confirmed MVI in 111 of the 201 patients (55.22%). The radiomics signature showed a favourable discriminatory ability for MVI in the training set (AUC, 0.896) and validation set (AUC, 0.788). The nomogram incorporating peritumoral enhancement, tumour growth type and radiomics signature showed good discrimination in the training (AUC, 0.932) and validation sets (AUC, 0.917) and achieved well-fitted calibration curves. Subgroup analysis showed that tumour growth type was a predictor for MVI in the HCC ≤ 3 cm cohort and peritumoral enhancement in the HCC > 3 cm cohort; radiomic features related to MVI varied between the HCC ≤ 3 cm and HCC > 3 cm cohort. The performance of the radiomics signature improved noticeably in both the HCC ≤ 3 cm (AUC, 0.953) and HCC > 3 cm cohorts (AUC, 0.993) compared to the original training set.

conclusionsThe preoperative nomogram integrating clinicoradiological risk factors and the MR radiomics signature showed favourable predictive efficiency for predicting MVI in patients with solitary HCC. The clinicoradiological factors and radiomic features related to MVI varied between subgroups (HCC ≤ 3 cm and > 3 cm). The performance of radiomics signature for MVI prediction was improved in both the subgroups.

Indexed as

hepatocellular carcinomamagnetic resonance imagingmicrovascular invasionnomogramradiomics analysis

Identifiers

PMID34692547
PMCPMC8529277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.