Evidence map›Paper›PMID 34692488›Full record

ArticleFrontiers in oncology2021

A Novel ZNF304/miR-183-5p/FOXO4 Pathway Regulates Cell Proliferation in Clear Cell Renal Carcinoma.

Li-Xin Ren, Bo-Wen Zeng, Meng Zhu, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang, Jun-Fei Gu, Zhan Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Li-Xin RenDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Bo-Wen ZengDepartment of Urology, Affiliated Hospital of Sergeant School of Army Medical University, Shijiazhuang, China.
Meng ZhuDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
An-Ning ZhaoDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Bei ShiDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Hong ZhangDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Dan-Dan WangDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jun-Fei GuDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Zhan YangDepartment of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Second Hospital of Hebei Medical University · CNHebei Medical University · CNArmy Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc-finger protein 304 (ZNF304) plays a critical role in silencing genes through transcription, regulating cell survival, proliferation, apoptosis, and differentiation during development. However, the roles of transcription factor ZNF304 and its clinical significance in clear cell renal carcinoma (ccRCC) remain unclear. In this study, we found that the expression of ZNF304 was downregulated in ccRCC tissues. Lower levels of ZNF304 were correlated with poor survival. Downregulation of ZNF304 promoted ccRCC cell growth

Indexed as

clear cell renal carcinoma (ccRCC)FOXO4miR-183-5pproliferationzinc-finger protein 304

Identifiers

PMID34692488
PMCPMC8529286
OpenAlexW3206621415

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.