Evidence map›Paper›PMID 34692299›Full record

ReviewCureus2021

Suicide by Opioid: Exploring the Intentionality of the Act.

Joseph Pergolizzi, Frank Breve, Peter Magnusson, Rohit Nalamasu, Jo Ann K LeQuang, Giustino Varrassi

Abstract readReview
In one paragraph

Review in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph PergolizziCardiology, Native Cardio, Inc., Naples, USA.
Frank BreveDepartment of Pharmacy, Temple University, Philadelphia, USA.
Peter MagnussonCardiology, Center of Research and Development Region Gävleborg, Uppsala University, Gävle, SWE.
Rohit NalamasuDepartment of Physical Medicine and Rehabilitation, University of Nebraska Medical Center, Omaha, USA.
Jo Ann K LeQuangPain Management, NEMA Research, Inc., Naples, USA.
Giustino VarrassiPain Management, Paolo Procacci Foundation, Rome, ITA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid toxicity can result in life-threatening respiratory depression. Opioid-overdose mortality in the United States is high and increasing, but it is difficult to determine what proportion of those deaths might actually be suicides. The exact number of Americans who died of an opioid overdose but whose deaths might be classified as suicide remains unknown. It is important to differentiate between those who take opioids with the deliberate and unequivocal objective of committing suicide, that is, those with active intent, from those with passive intent. The passive-intent group understands the risks of opioid consumption and takes dangerous amounts, but with a more ambiguous attitude toward suicide. Thus, among decedents of opioid overdose, a large population dies by accident, whereas a small population dies intending to commit suicide; but between them exists a sub-population with equivocal intentions, waxing and waning between their desire to live and the carelessness about death. There may be a passive as well as active intent to commit suicide, but less is known about the passive motivation. It is important for public health efforts aimed at reducing both suicides and opioid-use disorder to better understand the range of motivations behind opioid-related suicides and how to combat them.

Indexed as

mental health and suicideopioid epidemicopioid overdosesuicidal intentsuicidalitysuicidesuicide and depression

Identifiers

PMID34692299
PMCPMC8523441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.