Evidence map›Paper›PMID 34692255›Full record

ArticlePeerJ2021

Application of intra-arterial chemotherapy in high-risk non-muscle invasive bladder cancer: a systematic review and meta-analysis.

Chengyu You, Xianhui Li, Yuelin Du, Hui Wang, Xiaojun Zhang, Tangqiang Wei, Anguo Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chengyu YouNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
Xianhui LiNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
Yuelin DuNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
Hui WangNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
Xiaojun ZhangNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
Tangqiang WeiNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
Anguo WangNanchong Central Hospital, The Second Clinical College, North Sichuan Medical College, Nanchong, China.
North Sichuan Medical University · CNNanchong Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo summarize the current evidence on the effects of intra-arterial chemotherapy (IAC) on high-risk non-muscle invasive bladder cancer (NMIBC) and compare oncology results with intravesical chemotherapy (IVC).

methodsWe performed a systematic review and cumulative meta-analysis of the primary outcomes of interest by a systematical search of multiple scientific databases in February 2021. The mean difference (MD) and odds ratio (OR) were calculated for continuous and dichotomous variables respectively, with 95% confidence intervals (CIs). The hazard radio (HR) with 95% CIs was used for overall survival (OS), recurrence-free survival (RFS) and progression-free survival (PFS).

resultsA total of six studies with 866 patients were included. For IAC combined with IVC versus IVC alone, statistically significant differences were found regarding tumor recurrence rate (OR: 0.51, 95% CI [0.36∼0.72],

conclusionThe IAC combined with IVC is a safe and effective treatment for high risk NMIBC, with lower rates of recurrence, progression, tumor-specific death, PFS and RFS, and with minor and tolerable events. The effectiveness of the IAC alone is parallel to the IVC alone.

Indexed as

Bladder cancerIntra-arterial chemotherapyIntravesical chemotherapyRecurrenceSurvival

Identifiers

PMID34692255
PMCPMC8485834
OpenAlexW3204900718

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.