Evidence map›Paper›PMID 34692215›Full record

ArticleBiomedical optics express2021

High-speed multifocus phase imaging in thick tissue.

Sheng Xiao, Shuqi Zheng, Jerome Mertz

Abstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sheng XiaoDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.ORCID https://orcid.org/0000-0001-8959-2388
Shuqi ZhengDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.
Jerome MertzDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.ORCID https://orcid.org/0000-0002-6343-9155

Funding

Fast, large-scale neuronal imaging with multi-z confocal microscopyR01EB029171 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2020 to 2023
$1.8M
Development of label-free computational flow cytometry for high-throughput micro-organism classificationR21GM128020 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2018 to 2019
$446k
NIBIB NIH HHS R01 EB029171NIGMS NIH HHS R21 GM128020
6 · The paper itself

Abstract

Phase microscopy is widely used to image unstained biological samples. However, most phase imaging techniques require transmission geometries, making them unsuited for thick sample applications. Moreover, when applied to volumetric imaging, phase imaging generally requires large numbers of measurements, often making it too slow to capture live biological processes with fast 3D index-of-refraction variations. By combining oblique back-illumination microscopy and a z-splitter prism, we perform phase imaging that is both epi-mode and multifocus, enabling high-speed 3D phase imaging in thick, scattering tissues with a single camera. We demonstrate here 3D qualitative phase imaging of blood flow in chick embryos over a field of view of 546 × 546 × 137 µm

Identifiers

PMID34692215
PMCPMC8515987

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.