Evidence map›Paper›PMID 34692205›Full record

ArticleBiomedical optics express2021

Low-cost, chromatic confocal endomicroscope for cellular imaging

Nachiket Kulkarni, Andrew Masciola, Abhinav Nishant, Kyung-Jo Kim, Heejoo Choi, Arthur Gmitro, Esther E Freeman, Aggrey Semeere, Miriam Nakalembe, Dongkyun Kang

Abstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Optical imaging technologies forCurrent opinion in biomedical engineering · 2023
    Article
  5. Quantitative imaging in medicine and surgery · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nachiket KulkarniJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Andrew MasciolaDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, USA.
Abhinav NishantJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Kyung-Jo KimJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Heejoo ChoiJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Arthur GmitroJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
Esther E FreemanDepartment of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA.
Aggrey SemeereInfectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Miriam NakalembeInfectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Dongkyun KangJames C. Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.

Funding

Smartphone Confocal Endoscopy for Detecting Cervical PrecancerR21TW011222 · FIC · UNIVERSITY OF ARIZONA · PI KANG, DONGKYUN · 2018 to 2019
$412k
FIC NIH HHS R21 TW011222
6 · The paper itself

Abstract

We have developed a low-cost, chromatic confocal endomicroscope (CCE) that can image a cross-section of the tissue at cellular resolution. In CCE, a custom miniature objective lens was used to focus different wavelengths into different tissue depths. Therefore, each tissue depth was encoded with the wavelength. A custom miniature spectrometer was used to spectrally-disperse light reflected from the tissue and generate cross-sectional confocal images. The CCE prototype had a diameter of 9.5 mm and a length of 68 mm. Measured resolution was high, 2 µm and 4 µm for lateral and axial directions, respectively. Effective field size was 468 µm. Preliminary results showed that CCE can visualize cellular details from cross-sections of the tissue

Identifiers

PMID34692205
PMCPMC8515984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.