ArticleNational science review2020
Why does caloric restriction increase life and healthspan? The 'clean cupboards' hypothesis.
Article in National science review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The evolution of ageing: classic theories and emerging ideas.Biogerontology · 2024Review
- Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake.GeroScience · 2024Article
- The Potential of Fasting-Mimicking Diet as a Preventive and Curative Strategy for Alzheimer's Disease.Biomolecules · 2023Review
- The Effects of Graded Levels of Calorie Restriction: XIX. Impact of Graded Calorie Restriction on Protein Expression in the Liver.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Energy Allocation of the Wolf SpiderInsects · 2023Article
- Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?The FEBS journal · 2023Article
- A Life History Perspective on Athletes with Low Energy Availability.Sports medicine (Auckland, N.Z.) · 2022Review
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- Profile of John R. Speakman.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The effects of graded calorie restriction XVII: Multitissue metabolomics reveals synthesis of carnitine and NAD, and tRNA charging as key pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Transgenerational fitness effects of lifespan extension by dietary restriction inProceedings. Biological sciences · 2021Article
- A New Concept in Diet Restriction Is Cleaning Up!The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Of Mice and Men: Impacts of Calorie Restriction on Metabolomics of the Cerebellum.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes these problems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.