ArticleNational science review2019
Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution.
Article in National science review, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Brain-wide mapping and region-specific cellular characterization of Trhr1 reporter-labeled cells in mice using VISoR imaging.Brain structure & function · 2026Article
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- Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Modeling 3D mesoscaled neuronal complexity through learning-based dynamic morphometric convolution.Brain informatics · 2026Article
- One-step approach producing barcoded rabies virus with optimized diversity.Cell reports methods · 2025Article
- Development and application of a barcoded rabies viral tracing method for mapping brain-wide inputs to single neurons.Cell reports methods · 2025Article
- Whole-brain reconstruction of fiber tracts based on cytoarchitectonic organization.Nature methods · 2025Article
- Distributions of parvalbumin, calbindin-D28k, and calretinin in the cerebrum of Chinese tree shrews (Zoological research · 2025Article
- Single-Neuron Reconstruction of the Macaque Primary Motor Cortex Reveals the Diversity of Neuronal Morphology.Neuroscience bulletin · 2025Article
- IsoVISoR: Towards 3D Mesoscale Brain Mapping of Large Mammals at Isotropic Sub-micron Resolution.Neuroscience bulletin · 2025Article
- Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex.PLoS biology · 2025Article
- Self-supervised learning analysis of multi-FISH labeled cell-type map in thick brain slices.Frontiers in neuroscience · 2025Article
- Gapr for large-scale collaborative single-neuron reconstruction.Nature methods · 2024Article
- Acute Observational Stimulus of Restrained Mice Induced Anxiolytic Effects in Observer Mice.Neuroscience bulletin · 2024Article
- Expanding super-resolution imaging versatility in organisms with multi-confocal image scanning microscopy.National science review · 2024Article
- Advancing presurgical non-invasive molecular subgroup prediction in medulloblastoma using artificial intelligence and MRI signatures.Cancer cell · 2024Article
- NEATmap: a high-efficiency deep learning approach for whole mouse brain neuronal activity trace mapping.National science review · 2024Article
- Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system.Cell research · 2024Article
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits, which is of fundamental importance for neuroscience research. Here, we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout (VISoR) for high-throughput, high-quality brain mapping. Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion, the VISoR system effectively eliminates motion blur to obtain undistorted images. By continuously imaging moving samples without stopping, the system achieves high-speed 3D image acquisition of an entire mouse brain within 1.5 hours, at a resolution capable of visualizing synaptic spines. A pipeline is developed for sample preparation, imaging, 3D image reconstruction and quantification. Our approach is compatible with immunofluorescence methods, enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains. Using this system, we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-shEGFP mice under resting or forced swimming conditions. Our results indicate the involvement of multiple subcortical areas in stress response. Intriguingly, neuronal activation in these areas exhibits striking individual variability among different animals, suggesting the necessity of sufficient cohort size for such studies.
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