ArticleNational science review2021
Input associativity underlies fear memory renewal.
Article in National science review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Intraoperative temporal interference (TI)-noninvasive brain stimulation prevents postoperative delirium in mice.Fundamental research · 2026Article
- Neuropeptide Y co-opts neuronal ensembles for memory lability and stability.Nature neuroscience · 2026Article
- Identification of somatostatinProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural networks of the mouse visceromotor cortex.Nature · 2025Article
- Stress-Induced Endogenous Cannabinoid Signaling Contributes to Fear Generalization.Neuroscience bulletin · 2025Article
- Memory Trace for Fear Extinction: Fragile yet Reinforceable.Neuroscience bulletin · 2024Review
- Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons.National science review · 2024Article
- Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice.Environmental health perspectives · 2023Article
- Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory.Molecular psychiatry · 2022Article
- Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways.Nature communications · 2022Article
- Sex differences in the immediate extinction deficit and renewal of extinguished fear in rats.PloS one · 2022Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic associativity, a feature of Hebbian plasticity wherein coactivation of two inputs onto the same neuron produces synergistic actions on postsynaptic activity, is a primary cellular correlate of associative learning. However, whether and how synaptic associativity are implemented into context-dependent relapse of extinguished memory (i.e. fear renewal) is unknown. Here, using an auditory fear conditioning paradigm in mice, we show that fear renewal is determined by the associativity between convergent inputs from the auditory cortex (ACx) and ventral hippocampus (vHPC) onto the lateral amygdala (LA) that reactivate ensembles engaged during learning. Fear renewal enhances synaptic strengths of both ACx to LA and the previously unknown vHPC to LA monosynaptic inputs. While inactivating either of the afferents abolishes fear renewal, optogenetic activation of their input associativity in the LA recapitulates fear renewal. Thus, input associativity underlies fear memory renewal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.