Evidence map›Paper›PMID 34691605›Full record

ArticleNational science review2021

Single-cell yolk-shell nanoencapsulation for long-term viability with size-dependent permeability and molecular recognition.

Li Wang, Yu Li, Xiao-Yu Yang, Bo-Bo Zhang, Nöelle Ninane, Henk J Busscher, Zhi-Yi Hu, Cyrille Delneuville, Nan Jiang, Hao Xie and 3 more

Open access · goldAbstract read
In one paragraph

Article in National science review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. A Micrometric Transformer: Compositional Nanoshell Transformation of FeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Donors for nerve transplantation in craniofacial soft tissue injuries.Frontiers in bioengineering and biotechnology · 2022
    Review
  8. Review
  9. ACS applied materials & interfaces · 2021
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Li WangState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Yu LiState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Xiao-Yu YangState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Bo-Bo ZhangLaboratory of Inorganic Materials Chemistry (CMI), University of Namur, Namur B-5000, Belgium.
Nöelle NinaneNamur Research Institute for Life Sciences (Narilis), University of Namur, Namur B-5000, Belgium.
Henk J BusscherDepartment of Biomedical Engineering, University of Groningen and University Medical Centre Groningen, Groningen 9713 AV, The Netherlands.
Zhi-Yi HuState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Cyrille DelneuvilleLaboratory of Inorganic Materials Chemistry (CMI), University of Namur, Namur B-5000, Belgium.
Nan JiangState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Hao XieState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Gustaaf Van TendelooNanostructure Research Centre (NRC), Wuhan University of Technology, Wuhan 430070, China.
Tawfique HasanCambridge Graphene Centre, University of Cambridge, Cambridge CB3 0FA, UK.
Bao-Lian SuState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.ORCID https://orcid.org/0000-0001-8474-0652
University of Namur · BEWuhan University of Technology · CNHarvard University · USUniversity Medical Center Groningen · NLUniversity of Antwerp · BEUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Like nanomaterials, bacteria have been unknowingly used for centuries. They hold significant economic potential for fuel and medicinal compound production. Their full exploitation, however, is impeded by low biological activity and stability in industrial reactors. Though cellular encapsulation addresses these limitations, cell survival is usually compromised due to shell-to-cell contacts and low permeability. Here, we report ordered packing of silica nanocolloids with organized, uniform and tunable nanoporosities for single cyanobacterium nanoencapsulation using protamine as an electrostatic template. A space between the capsule shell and the cell is created by controlled internalization of protamine, resulting in a highly ordered porous shell-void-cell structure formation. These unique yolk-shell nanostructures provide long-term cell viability with superior photosynthetic activities and resistance in harsh environments. In addition, engineering the colloidal packing allows tunable shell-pore diameter for size-dependent permeability and introduction of new functionalities for specific molecular recognition. Our strategy could significantly enhance the activity and stability of cyanobacteria for various nanobiotechnological applications.

Indexed as

cell surface engineeringharsh condition resistancehigh photosynthetic abilityordered colloidal packingprotein internalizationthiol-functionalization

Identifiers

PMID34691605
PMCPMC8288456
OpenAlexW3022172451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.