Evidence map›Paper›PMID 34691354›Full record

ArticleOxidative medicine and cellular longevity2021

Protective Effects of Low-Dose Alcohol against Acute Stress-Induced Renal Injury in Rats: Involvement of CYP4A/20-HETE and LTB

Yongping Chen, Haotian Yang, Tianyuan Yang, Haiyang Zhang, Yuan Zhao, Lin Li, Honggang Fan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yongping ChenCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID https://orcid.org/0000-0003-3990-056X
Haotian YangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Tianyuan YangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Haiyang ZhangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yuan ZhaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Lin LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Honggang FanCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID https://orcid.org/0000-0002-7671-6908
Northeast Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-dose alcohol possesses multiple bioactivities. Accordingly, we investigated the protective effect and related molecular mechanism of low-dose alcohol against acute stress- (AS-) induced renal injury. Herein, exhaustive swimming for 15 min combined with restraint stress for 3 h was performed to establish a rat acute stress model, which was verified by an open field test. Evaluation of renal function (blood creatinine and urea nitrogen), urine test (urine leukocyte esterase and urine occult blood), renal histopathology, oxidative stress, inflammation, and apoptosis was performed. The key indicators of the cytochrome P450 (CYP) 4A1/20-hydroxystilbenetetraenoic acid (20-HETE) pathway, cyclooxygenase (COX)/prostaglandin E

Indexed as

Acute Kidney InjuryAlcohol DrinkingAnimalsCytochrome P-450 CYP4ALeukotriene B4MaleRatsRats, WistarCytochrome P-450 CYP4ALeukotriene B4

Identifiers

PMID34691354
PMCPMC8528604
OpenAlexW3205402678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.