Evidence map›Paper›PMID 34691317›Full record

Trial reportPain research & management

The Efficacy of Moxibustion on the Serum Levels of CXCL1 and

Siyu Tao, Xue Wang, Chenxi Liao, Yan Xiong, Jie Tang, Nannan Jiang, Yuan Li, Xinyue Hu, Rouxian Shuai, Yueyue Wang and 1 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Formation of a β-Endorphin Corona Mitigates Alzheimer's Amyloidogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Siyu TaoChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.ORCID https://orcid.org/0000-0002-5092-1743
Xue WangChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Chenxi LiaoChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Yan XiongWest China Fourth Hospital, Chengdu 610075, Sichuan Province, China.
Jie TangChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Nannan JiangChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Yuan LiChengdu University of Traditional Chinese Medicine Affiliated Hospital, Chengdu 610075, Sichuan Province, China.
Xinyue HuChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Rouxian ShuaiChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Yueyue WangSichuan Integrative Medicine Hospital, Chengdu 610075, Sichuan Province, China.
Ping WuChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.ORCID https://orcid.org/0000-0003-4062-9447
Chengdu University of Traditional Chinese Medicine · CNFourth People's Hospital of Sichuan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to evaluate the efficacy of moxibustion on joint swelling and pain and the levels of C-X-C motif chemokine ligand 1 (CXCL1),

methodsSixty-eight patients with RA were randomly and equally classified into the control and treatment groups. The control group was treated with routine drug therapy, while the treatment group received routine drug therapy and moxibustion. Both groups were treated for eight weeks. The symptoms and laboratory indicators of RA patients were compared in the two groups before and after intervention.

resultsSixty-one patients completed the study: four patients dropped out from the treatment group and three from the control group. Trial endpoints were change (∆) in symptoms, measured by Ritchie's articular index (RAI), swollen joint count (SJC), and laboratory indicators, measured by the level of CXCL1,

conclusionMoxibustion can improve the joint swelling and pain symptoms in patients with RA, which may be related to the fact that moxibustion can reduce the release of inflammatory factors in patients with RA and downregulate the level of CXCL1 and increase the level of

Indexed as

Arthritis, RheumatoidMoxibustionAnti-Inflammatory Agentsbeta-EndorphinChemokine CXCL1HumansTumor Necrosis Factor-alphaAnti-Inflammatory Agentsbeta-EndorphinChemokine CXCL1CXCL1 protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID34691317
PMCPMC8528578
OpenAlexW3207835094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.