Evidence map›Paper›PMID 34691300›Full record

ArticleWideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques2021

Effect of dexmedetomidine on opioid consumption and pain control after laparoscopic cholecystectomy: a meta-analysis of randomized controlled trials.

Yang Liu, Guomin Zhao, Xuefeng Zang, Feiping Lu, Ping Liu, Wei Chen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07231926 (The Effects of Intrathecal Morphine in Addition to Serratus Anterior Plane Block and Dexmedetomidine on Postoperative Recovery), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07231926 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of Intrathecal Morphine in Addition to Serratus Anterior Plane Block and Dexmedetomidine on Postoperative Recovery (QoR-15) and Systemic Inflammation in Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorAtaturk UniversityRan2025 to 2026Enrolled52ConditionsPostoperative Pain Management in Video-Assisted Thoracoscopic SurgeryArmsIntrathecal Morphine, Serratus Anterior Plane Block (SAPB) group, Dexmedetomidine
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. The Role of Dexmedetomidine in Burn Care: Sedation, Analgesia, and Beyond.Journal of burn care & research : official publication of the American Burn Association · 2026
    Review
  3. Observational
  4. Review
  5. Effect of dexmedetomidine on perioperative haemodynamics and early cognitive function in elderly patients undergoing laparoscopic surgery.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yang LiuDepartment of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Guomin ZhaoDepartment of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Xuefeng ZangDepartment of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Feiping LuDepartment of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Ping LiuDepartment of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Wei ChenDepartment of Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Shijitan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe clinical evidence on dexmedetomidine (DEX) for postoperative pain scores and opioid consumption remains unclear in laparoscopic cholecystectomy (LC).

aimTo evaluate whether DEX could reduce opioid consumption and pain control after LC. MATERIAL AND

methodsA meta-analysis search of EMBASE, PubMed and Cochrane CENTRAL databases was performed and randomized controlled trials (RCTs) comparing DEX with control for adult patients undergoing LC were searched. The primary outcome was opioid consumption in the first 24 h after the operation. The secondary outcomes were the time of first request of analgesia, visual analogue scale (VAS) scores 24 h after the operation, the incidence of patients' need for rescue analgesics, opioid-related adverse effects, DEX-related adverse effects and other complications.

resultsThere were fourteen aspects of twelve trials and 967 patients included in the analysis. DEX use significantly reduced the opioid consumption in the first 24 h after the operation (weighted mean difference (WMD), -19.17; 95% confidence interval (CI), -30.29 to -8.04; p = 0.0007), lengthened the time of first request of analgesia (WMD = 38.90; 95% CI: 0.88-76.93; p = 0.04) and lowered post-operative nausea or vomiting (PONV) (odds ratio (OR) = 0.49; 95% CI: 0.27-0.89; p = 0.02).

conclusionsIntravenous DEX infusion significantly improved the duration of the analgesic effect and reduced postoperative opioid consumption. Moreover, lower incidence of post-operative nausea or vomiting was found in the DEX group.

Indexed as

dexmedetomidinemeta-analysisopioid consumptionpainvisual analogue scale

Identifiers

PMID34691300
PMCPMC8512507
OpenAlexW3134872625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.