Evidence map›Paper›PMID 34691193›Full record

ArticleStem cells international2021

ALK5 i II Accelerates Induction of Adipose-Derived Stem Cells toward Schwann Cells through a Non-Smad Signaling Pathway.

Seiji Sawai, Tsunao Kishida, Shin-Ichiro Kotani, Shinji Tsuchida, Ryo Oda, Hiroyoshi Fujiwara, Kenji Takahashi, Osam Mazda, Yoshihiro Sowa

Erratum issuedAbstract read
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In one paragraph

Article in Stem cells international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Seiji SawaiDepartment of Orthopedics, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Tsunao KishidaDepartment of Immunology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Shin-Ichiro KotaniDepartment of Immunology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Shinji TsuchidaDepartment of Orthopedics, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Ryo OdaDepartment of Orthopedics, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Hiroyoshi FujiwaraDepartment of Orthopedics, Japanese Red Cross Society Kyoto Daini Hospital, Kyoto 602-8026, Japan.
Kenji TakahashiDepartment of Orthopedics, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Osam MazdaDepartment of Immunology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.
Yoshihiro SowaDepartment of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto 602-8566, Japan.ORCID https://orcid.org/0000-0002-7112-1630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schwann cells (SCs) are likely to be a vital component of cell-based therapies for nerve regeneration. There are various methods for inducing SC-like cells (SCLCs) from adipose-derived stem cells (ADSCs), but their phenotypic and functional characteristics remain unsatisfactory. Here, we report a novel efficient procedure to induce SCLCs by culturing ADSCs with ALK5 inhibitor (ALK5 i) II, a specific inhibitor of activin-like kinase 5 (ALK5) (transforming growth factor-

Identifiers

PMID34691193
PMCPMC8536445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.