Evidence map›Paper›PMID 34691079›Full record

ArticleFrontiers in immunology2021

Dynamics of T-Lymphocyte Activation Related to Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in Persons With Advanced HIV.

Rafael Tibúrcio, Beatriz Barreto-Duarte, Gopolan Naredren, Artur T L Queiroz, Selvaraj Anbalagan, Kaustuv Nayak, Narayanan Ravichandran, Rajasekaran Subramani, Lis R V Antonelli, Kumar Satagopan and 6 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. CD8CNS neuroscience & therapeutics · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Frequency of CXCR3Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Rafael TibúrcioLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Beatriz Barreto-DuarteLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Gopolan NaredrenDepartment of Clinical Research, National Institute for Research in Tuberculosis, Chennai, India.
Artur T L QueirozMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.
Selvaraj AnbalaganDepartment of Clinical Research, National Institute for Research in Tuberculosis, Chennai, India.
Kaustuv NayakDepartment of Clinical Research, National Institute for Research in Tuberculosis, Chennai, India.
Narayanan RavichandranGovernment Hospital of Thoracic Medicine, Chennai, India.
Rajasekaran SubramaniDepartment of Clinical Research, National Institute for Research in Tuberculosis, Chennai, India.
Lis R V AntonelliLaboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Kumar SatagopanGovernment Hospital of Thoracic Medicine, Chennai, India.
Komathi AnbalaganGovernment Hospital of Thoracic Medicine, Chennai, India.
Brian O PorterHIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Alan SherImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Soumya SwaminathanWellcome Trust Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Irini SeretiHIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Bruno B AndradeLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
National Institute of Research in Tuberculosis · INFundação Oswaldo Cruz · BRGovernment Hospital of Thoracic Medicine · INNational Institutes of Health · USEscola Bahiana de Medicina e Saúde Pública · BRUniversidade Salvador · BRUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most persons living with HIV (PLWH) experience a significant restoration of their immunity associated with successful inhibition of viral replication after antiretroviral therapy (ART) initiation. Nevertheless, with the robust quantitative and qualitative restoration of CD4

Indexed as

Lymphocyte ActivationAcquired Immunodeficiency SyndromeAnti-HIV AgentsBiomarkersCD4-CD8 RatioCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytotoxicity, ImmunologicHumansImmune Reconstitution Inflammatory SyndromeImmunophenotypingLymphopeniaMycobacterium tuberculosisObservational Studies as TopicRandomized Controlled Trials as TopicRetrospective StudiesAnti-HIV AgentsBiomarkersinflammationIRIS pathogenesisTB-HIV coinfectionT cell activationT lymphocytes

Identifiers

PMID34691079
PMCPMC8529328
OpenAlexW3203126416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.