Evidence map›Paper›PMID 34691060›Full record

ArticleFrontiers in immunology2021

Determinants of Ligand Specificity and Functional Plasticity in Type I Interferon Signaling.

Duncan Kirby, Baljyot Parmar, Sepehr Fathi, Sagar Marwah, Chitra R Nayak, Vera Cherepanov, Sonya MacParland, Jordan J Feld, Grégoire Altan-Bonnet, Anton Zilman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Duncan KirbyDepartment of Physics, University of Toronto, Toronto, ON, Canada.
Baljyot ParmarDepartment of Physics, University of Toronto, Toronto, ON, Canada.
Sepehr FathiDepartment of Physics, University of Toronto, Toronto, ON, Canada.
Sagar MarwahAjmera Family Transplant Centre, Toronto General Research Institute, Departments of Laboratory Medicine and Pathobiology and Immunology, University of Toronto, Toronto, ON, Canada.
Chitra R NayakDepartment of Physics, University of Toronto, Toronto, ON, Canada.
Vera CherepanovSandra Rotman Centre for Global Health, Toronto General Research Institute, University of Toronto, Toronto, ON, Canada.
Sonya MacParlandAjmera Family Transplant Centre, Toronto General Research Institute, Departments of Laboratory Medicine and Pathobiology and Immunology, University of Toronto, Toronto, ON, Canada.
Jordan J FeldToronto Centre for Liver Disease, University Health Network, Toronto, ON, Canada.
Grégoire Altan-BonnetImmunodynamics Group, Laboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD, United States.
Anton ZilmanDepartment of Physics, University of Toronto, Toronto, ON, Canada.
University of Toronto · CACenter for Cancer Research · USCentre for Global Health Research · CAToronto General Hospital · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Type I Interferon family of cytokines all act through the same cell surface receptor and induce phosphorylation of the same subset of response regulators of the STAT family. Despite their shared receptor, different Type I Interferons have different functions during immune response to infection. In particular, they differ in the potency of their induced anti-viral and anti-proliferative responses in target cells. It remains not fully understood how these functional differences can arise in a ligand-specific manner both at the level of STAT phosphorylation and the downstream function. We use a minimal computational model of Type I Interferon signaling, focusing on Interferon-

Indexed as

Models, ImmunologicalAnimalsComputer SimulationDimerizationFeedback, PhysiologicalFemaleHumansInhibitory Concentration 50Interferon-alphaInterferon-betaKineticsLigandsMiceMice, Inbred C57BLProtein BindingProtein Interaction MappingInterferon-alphaInterferon-betaLigandsReceptor, Interferon alpha-betaSTAT Transcription FactorsSuppressor of Cytokine Signaling 1 ProteinUbiquitin Thiolesterasecellular decision makingfunctional plasticityligand specificitysignal processingtype I interferon (IFN) signaling

Identifiers

PMID34691060
PMCPMC8529159
OpenAlexW3205709856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.