Evidence map›Paper›PMID 34691025›Full record

ArticleFrontiers in immunology2021

Nonspecific Regulation of the Number of Immunocompetent Cells Under the Influence of DT Toxoid in Children With Glomerulonephritis.

Mikhail Petrovich Kostinov, Nelli Kimovna Akhmatova, Olga Olegovna Magarshak, Anna Egorovna Vlasenko, Valentina Borisovna Polishchuk, Aristitsa Mikhailovna Kostinova, Kirill Vadimovich Mashilov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mikhail Petrovich KostinovDepartment of Allergology, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Nelli Kimovna AkhmatovaDepartment of Immunology, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Olga Olegovna MagarshakDepartment of Immunology, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Anna Egorovna VlasenkoDepartment of Medical Cybernetics and Computer Science Novokuznetsk State Institute for Advanced Training of Physicians, Branch Campus of the Russian Medical Academy of Continuous Professional Education, Novokuznetsk, Russia.
Valentina Borisovna PolishchukDepartment of Allergology, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Aristitsa Mikhailovna KostinovaDepartment of Immunology, NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
Kirill Vadimovich MashilovDepartment of Allergology, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences · RUInstitute of Immunology and Physiology · RURussian Medical Academy of Continuous Professional Education · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies aimed at identifying the mechanisms of the immunoregulatory effect of vaccination with diphtheria and tetanus toxoid on the parameters of adaptive immunity in children with kidney pathology are limited. The study aimed to study the effect of revaccination against diphtheria and tetanus on the proliferation and differentiation of immunocompetent cells, the formation of specific antibodies, and the course of the disease in children with glomerulonephritis (GN). Methods: The study included 45 children with glomerulonephritis (GN) aged 5 to 15 years, in remission from 6 months up to 4 years. Of these, 25 children were revaccinated with DT toxoid (Diphtheria-Tetanus toxoid with reduced antigenic content) and 20 were in the control group (not vaccinated). The frequency of development of local and systemic reactions and the course of GN were assessed. The subpopulation structure of lymphocytes was studied in dynamics after 1-6-12 months by flow cytometry and IgG levels to diphtheria and tetanus were studied by ELISA. Results: In 92% of children with GN, the post-vaccination period was uneventful. 8% showed a rise in temperature up to 37.3 Conclusion: Revaccination with DT toxoid in children with GN not only does not cause undesirable changes in the system of immunocompetent cells but also has an immunomodulatory effect, which contributes to the favorable maintenance of the remission period of the disease.

Indexed as

ImmunomodulationAdolescentAge FactorsAntibodies, BacterialCase-Control StudiesChildChild, PreschoolComorbidityFemaleGlomerulonephritisHumansImmunityImmunization, SecondaryImmunoglobulin GLymphocyte CountMaleAntibodies, BacterialImmunoglobulin GTetanus Toxoiddiphtheria and tetanus toxoidglomerulonephritispost-vaccination antibodiesT-Lymphocytesvaccination in children

Identifiers

PMID34691025
PMCPMC8527030
OpenAlexW3203010895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.