Evidence map›Paper›PMID 34691019›Full record

ArticleFrontiers in immunology2021

Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis.

Pedro Paulo Carneiro, Andreza S Dórea, Walker N Oliveira, Luiz Henrique Guimarães, Claúdia Brodskyn, Edgar M Carvalho, Olívia Bacellar

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Frontiers in immunology · 2023
    Article
  7. Unwinding the mechanism of macrophage repolarization potential ofFrontiers in cellular and infection microbiology · 2023
    Article
  8. Article
  9. Frontiers in immunology · 2023
    Article
  10. Article
  11. Protection and Pathology inPathogens (Basel, Switzerland) · 2022
    Review
  12. Immune Responses in Leishmaniasis: An Overview.Tropical medicine and infectious disease · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Pedro Paulo CarneiroServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Andreza S DóreaServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Walker N OliveiraServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Luiz Henrique GuimarãesFaculdade de Medicina, Universidade Federal do Sul da Bahia, Teixeira de Freitas, Brazil.
Claúdia BrodskynGoncalo Moniz Institute (IGM), Fiocruz, Salvador, Brazil.
Edgar M CarvalhoGoncalo Moniz Institute (IGM), Fiocruz, Salvador, Brazil.
Olívia BacellarServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Complexo Hospitalar Universitário Professor Edgard Santos · BRFundação Oswaldo Cruz · BRInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais · BRUniversidade Federal da Bahia · BRUniversidade Federal do Sul da Bahia · BR

Funding

Inflammation in the Pathogenesis of Disseminated LeishmaniasisU01AI136032 · NIAID · FEDERAL UNIVERSITY OF BAHIA · PI CARVALHO, EDGAR M · 2017 to 2021
$1.6M
NIAID NIH HHS U01 AI136032
6 · The paper itself

Abstract

Human cutaneous leishmaniasis (CL) caused by

Indexed as

AdolescentAdultCells, CulturedFemaleHumansInflammationLeishmaniasis, CutaneousLeukocytes, MononuclearMaleMiddle AgedParasite LoadToll-Like Receptor 2Toll-Like Receptor 4Young AdultTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4cutaneous leishmaniasiscytokinesinnate immunityLeishmania braziliensistoll-like receptors

Identifiers

PMID34691019
PMCPMC8526941
OpenAlexW3203292078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.