Evidence map›Paper›PMID 34690820›Full record

ArticleFrontiers in physiology2021

Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation.

Isato Fukushi, Kotaro Takeda, Mieczyslaw Pokorski, Yosuke Kono, Masashi Yoshizawa, Yohei Hasebe, Akito Nakao, Yasuo Mori, Hiroshi Onimaru, Yasumasa Okada

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Minocycline prevents hypoxia-induced seizures.Frontiers in neural circuits · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Isato FukushiFaculty of Health Sciences, Uekusa Gakuen University, Chiba, Japan.
Kotaro TakedaClinical Research Center, Murayama Medical Center, Musashimurayama, Japan.
Mieczyslaw PokorskiInstitute of Health Sciences, University of Opole, Opole, Poland.
Yosuke KonoClinical Research Center, Murayama Medical Center, Musashimurayama, Japan.
Masashi YoshizawaClinical Research Center, Murayama Medical Center, Musashimurayama, Japan.
Yohei HasebeClinical Research Center, Murayama Medical Center, Musashimurayama, Japan.
Akito NakaoLaboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Yasuo MoriLaboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Hiroshi OnimaruDepartment of Physiology, Showa University School of Medicine, Tokyo, Japan.
Yasumasa OkadaClinical Research Center, Murayama Medical Center, Musashimurayama, Japan.
Murayama Medical Center · JPKyoto University · JPUniversity of Yamanashi · JPJan Długosz University · PLShowa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute hypoxia increases ventilation. After cessation of hypoxia loading, ventilation decreases but remains above the pre-exposure baseline level for a time. However, the mechanism of this post-hypoxic persistent respiratory augmentation (PHRA), which is a short-term potentiation of breathing, has not been elucidated. We aimed to test the hypothesis that astrocytes are involved in PHRA. To this end, we investigated hypoxic ventilatory responses by whole-body plethysmography in unanesthetized adult mice. The animals breathed room air, hypoxic gas mixture (7% O

Indexed as

arundic acidastrocytehypoxiaplasticitypost-hypoxic respiratory augmentationrespiratory controlshort-term potentiationTRPA1

Identifiers

PMID34690820
PMCPMC8531090
OpenAlexW3205855836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.