Evidence map›Paper›PMID 34690777›Full record

ArticleFrontiers in pharmacology2021

Extracellular Vesicle Proteins and MicroRNAs Are Linked to Chronic Post-Traumatic Stress Disorder Symptoms in Service Members and Veterans With Mild Traumatic Brain Injury.

Vivian A Guedes, Chen Lai, Christina Devoto, Katie A Edwards, Sara Mithani, Dilorom Sass, Rany Vorn, Bao-Xi Qu, Heather L Rusch, Carina A Martin and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026
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  19. Extracellular Vesicles in Mental Disorders: A State-of-art Review.International journal of biological sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Vivian A GuedesTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Chen LaiTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Christina DevotoTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Katie A EdwardsTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Sara MithaniTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Dilorom SassTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Rany VornTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Bao-Xi QuTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Heather L RuschTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Carina A MartinTissue Injury Branch, National Institutes of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
William C WalkerDepartment of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, United States.
Elisabeth A WildeCENC Neuroimaging Core, George E. Wahlen VA Salt Lake City Healthcare System and Traumatic Brain Injury and Concussion Center, Department of Neurology, University of Utah, Salt Lake City, UT, United States.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Jessica M GillCENC Biorepository, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Kimbra KenneyCENC Biorepository, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
National Institute of Nursing Research · USNational Institutes of Health · USUniformed Services University of the Health Sciences · USUniversity of Pennsylvania · USVA Salt Lake City Healthcare System · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Symptoms of post-traumatic stress disorder (PTSD) are common in military populations, and frequently associated with a history of combat-related mild traumatic brain injury (mTBI). In this study, we examined relationships between severity of PTSD symptoms and levels of extracellular vesicle (EV) proteins and miRNAs measured in the peripheral blood in a cohort of military service members and Veterans (SMs/Vs) with chronic mTBI(s). Participants (

Indexed as

biomarkersconcussionexosomesmilitaryneurofilament light (NfL)PTSD

Identifiers

PMID34690777
PMCPMC8526745
OpenAlexW3204537306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.