ArticleFrontiers in aging neuroscience2021
Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- Functional remapping in networks of the Parkinsonian brain: A preclinical neuroimaging perspective with clinical correlates.Translational neuroscience · 2025Review
- Accelerometer-based and self-reported physical activity and sedentary time and their relationships with the P300 in a Go/No-Go task in older adults.Brain and cognition · 2024Article
- Self-reported mid- to late-life physical and recreational activities: Associations with late-life cognition.Journal of the International Neuropsychological Society : JINS · 2024Article
- Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome.Brain structure & function · 2023Article
- Neural Synchrony During Naturalistic Information Processing Is Associated With Aerobically Active Lifestyle and Cardiorespiratory Fitness in Cognitively Intact Older Adults.Frontiers in human neuroscience · 2022Article
- Cognition and Cognitive Reserve in Cochlear Implant Recipients.Frontiers in aging neuroscience · 2022Article
- Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in hippocampal function have been shown in older adults, which are expressed as changes in hippocampal activity and connectivity. While hippocampal activation during memory demands has been demonstrated to decrease with age, some older individuals present increased activity, or hyperactivity, of the hippocampus which is associated with increased neuropathology and poor memory function. In addition, lower functional coherence between the hippocampus and core hubs of the default mode network (DMN), namely, the posteromedial and medial prefrontal cortices, as well as increased local intrahippocampal connectivity, were also demonstrated in cognitively intact older adults. Aerobic exercise has been shown to elicit neuroprotective effects on hippocampal structure and vasculature in aging, and improvements in cardiorespiratory fitness have been suggested to mediate these exercise-related effects. However, how these lifestyle factors relate to hippocampal function is not clear. Fifty-two cognitively intact older adults (aged 65-80 years) have been recruited and divided into physically active (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.