Evidence map›Paper›PMID 34690623›Full record

ArticleAnnals of microbiology2021

Co-administration of vitamin D3 and

Ignazio Castagliuolo, Melania Scarpa, Paola Brun, Giulia Bernabe, Valeria Sagheddu, Marina Elli, Walter Fiore, Valerio De Vitis, Simone Guglielmetti

Open access · goldAbstract read
In one paragraph

Article in Annals of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Vitamin DBiomolecules · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Effects of Probiotics and Vitamin DSports medicine - open · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ignazio CastagliuoloDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Melania ScarpaDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Paola BrunDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Giulia BernabeDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy.
Valeria SaghedduAAT-Advanced Analytical Technologies S.r.l., Fiorenzuola d'Arda, Piacenza, Italy.
Marina ElliAAT-Advanced Analytical Technologies S.r.l., Fiorenzuola d'Arda, Piacenza, Italy.
Walter FioreSOFAR S.p.A., Trezzano Rosa, Milan, Italy.
Valerio De VitisSOFAR S.p.A., Trezzano Rosa, Milan, Italy.
Simone GuglielmettiDivision of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, 20133 Milan, Italy.ORCID 0000-0002-8673-8190
University of Padua · ITSofar (Italy) · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSubclinical vitamin D (vitD) deficiency enhances the predisposition to a myriad of acute and chronic pathologies in many people worldwide. Due to the scarcity of vitD-rich foods, the consumption of supplements or fortified foods can be required to maintain healthy serum levels of 25-hydroxyvitamin D [25(OH)D], and the major circulating form of vitD that is commonly measured in serum to determine the vitD status. Since the vitD absorption seems to resemble that of lipids, improved emulsification in the gut could favor vitD permeation through the enterocyte membrane. Contextually, we hypothesized that a microorganism with cholecalciferol (vitD3)-solubilization properties may potentially result in enhanced serum vitD levels. METHODS AND

resultsSix probiotic strains were screened for their ability to create a stable suspension of vitD3 in water:

conclusionThis preliminary pre-clinical study suggests that the combined administration of

Indexed as

BioavailabilityBiosurfactantCholecalciferol supplementationProbioticsVitamin D

Identifiers

PMID34690623
PMCPMC8522538
OpenAlexW3205495337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.