ArticleFocus (American Psychiatric Publishing)2021
Late Life Depression: The Essentials and the Essential Distinctions.
Article in Focus (American Psychiatric Publishing), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Smartphone-Based Passive Sensing of Activity Levels and Behavioral Activation During Psychosocial Interventions for Older Adults With Depression: Longitudinal Observational Study.Journal of medical Internet research · 2026Observational
- Childhood mental health and major depression in later life: a survival analysis across 12 years.Aging & mental health · 2026Article
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- Heterogeneity of depressive symptoms and associated factors in Korean adults: a latent class analysis using a national data survey.Journal of Korean biological nursing science · 2026Article
- A Novel Polygenic Risk Score Indexing Somatostatin-Expressing Inhibitory Neurons Predicts Somatostatin-Expressing Cell Proportions and Severity of Symptoms in Late-Life Depression.Biological psychiatry global open science · 2026Article
- Nonlinear threshold and association of depressive symptoms with pain in middle-aged and older Chinese adults: a cross-sectional and cohort study.Scientific reports · 2026Article
- Molecular Mechanisms of Accelerated Ageing in Geriatric Depression: Interplay of Telomere Attrition, Mitochondrial Dysfunction and Cellular Senescence.International journal of molecular sciences · 2026Review
- Depressive symptoms in hospitalized geriatric patients with and without cognitive impairment: a cross-sectional network analysis approach.Frontiers in medicine · 2026Article
- Why some minds bend, not break: an exploratory study of cognitive and psychological performance across levels of cognitive reserve in subjective cognitive decline.Frontiers in psychology · 2026Article
- Experiences and Perceptions of Functional Recovery in Late-Life Depression: A Qualitative Study.International journal of mental health nursing · 2025Article
- Changes in Neural Activities and Neuroplasticity Related to Nonpharmacological Interventions for Major Depressive Disorder: A Systematic Literature Review.Biological psychiatry global open science · 2025Review
- Association of semaglutide use with depressive symptoms and suicidal behavior in a patient with type 2 diabetes: A case report.The Journal of international medical research · 2025Article
- Assessment Teams Experience of Barriers and Challenges When Assessing Loneliness and Depression Among Home-Dwelling Elderly: A Qualitative Study.Scandinavian journal of caring sciences · 2025Article
- Identifying comorbidity patterns of mental health disorders in community-dwelling older adults: a cluster analysis.BMC geriatrics · 2025Article
- Cognitive Deficits in Late-Life Depression: From Symptoms and Assessment to Therapeutics.Focus (American Psychiatric Publishing) · 2025Review
- The Role of Chronic Disease Numbers in the Relationship Between Living Alone and Depression: A Four-Way Decomposition Analysis in a Cross-Sectional Study of Older Adults.Clinical interventions in aging · 2025Article
- Associations of depressive symptoms, social engagement and support, and lifestyle behaviors among non-Hispanic black and Hispanic men with chronic conditions in the United States.Frontiers in public health · 2025Article
- Advances in the assessment and study of suicide in late-life depression.Frontiers in psychiatry · 2025Review
- How trustworthy and applicable is the evidence from systematic reviews of depression treatments: Protocol for systematic examination.PloS one · 2025Article
- The association of late-life depressive symptoms with brain amyloid-β deposition: the ARIC-PET study.Aging brain · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late life depression (LLD), a familiar syndrome, is not differentiated in the DSM-5. LLD can resemble depressive syndromes in younger adults but it differs in demographic characteristics, phenomenology, prognosis, treatment, suicide risk, relationship to other disorders, and etiology. Older depressed adults often present with fewer major depressive symptoms, less emphasis on mood disturbance, greater preoccupation with somatic or psychotic symptoms, and misleading cognitive deficits. LLD's relationships with medical and neurocognitive symptoms and with inflammatory and immune factors are complex. Formal screening tools and biopsychosocial assessment informs diagnosis and treatment. Evidence supports the effectiveness of lifestyle interventions, several psychotherapies, and a variety of somatic treatment approaches. Comorbid medical disorders must be taken into account when planning treatment. In this article, the authors describe the characteristics of LLD, present an approach to assessment and management, and recommend that future DSM editions include a new specifier to differentiate LLD from other depressive syndromes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.