Evidence map›Paper›PMID 34690420›Full record

ArticleMRS bulletin2020

Recent advances in neural interfaces-Materials chemistry to clinical translation.

Christopher J Bettinger, Melanie Ecker, Takashi Daniel Yoshida Kozai, George G Malliaras, Ellis Meng, Walter Voit

Abstract read
In one paragraph

Article in MRS bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Chronic alteration of CabioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Innovative solutions for disease management.Bioelectronic medicine · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Dexamethasone-Enhanced Microdialysis and Penetration Injury.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher J BettingerDepartment of Materials Science and Engineering, and Department of Biomedical Engineering, Carnegie Mellon University, USA.
Melanie EckerDepartment of Biomedical Engineering, University of North Texas, USA.
Takashi Daniel Yoshida KozaiDepartment of Bioengineering, University of Pittsburgh, USA.
George G MalliarasUniversity of Cambridge, UK.
Ellis MengDepartment of Electrical and Computer Engineering, University of Southern California, Los Angeles, USA.
Walter VoitDepartment of Mechanical Engineering, The University of Texas at Dallas, USA.

Funding

A Technology Resource for Polymer Microelectrode ArraysU24NS113647 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MENG, ELLIS, SONG, DONG · 2019 to 2023
$6.1M
Subcellular Wireless Axons for in vivo Localized Neuronal ExcitationR01NS105691 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Takashi Daniel Yoshida Kozai, Wen Li · 2020 to 2026
$3.1M
Mechanisms behind Electrode Induced BBB damage's impact on neural recordingR01NS094396 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOZAI, TAKASHI DANIEL YOSHIDA · 2015 to 2019
$2.2M
Flexible neural probe arrays for large-scale cortical and subcortical recordingU01NS099703 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MENG, ELLIS · 2016 to 2018
$1.2M
Hydrogel Multielectrode Arrays for Therapeutic Peripheral Nerve StimulationR21NS095250 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI BETTINGER, CHRISTOPHER JOHN · 2015 to 2016
$409k
Exploring the role of Oligodendrocytes and progenitors on chronic brain implantsR21NS108098 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOZAI, TAKASHI DANIEL YOSHIDA · 2018 to 2019
$387k
Microstructured Intestinal Retentive Devices for Sustained Oral DeliveryR21EB026073 · NIBIB · CARNEGIE-MELLON UNIVERSITY · PI BETTINGER, CHRISTOPHER JOHN · 2019 to 2021
$386k
NIBIB NIH HHS R21 EB026073NINDS NIH HHS R01 NS094396NINDS NIH HHS R01 NS105691NINDS NIH HHS R21 NS095250NINDS NIH HHS R21 NS108098NINDS NIH HHS U01 NS099703NINDS NIH HHS U24 NS113647
6 · The paper itself

Abstract

Implantable neural interfaces are important tools to accelerate neuroscience research and translate clinical neurotechnologies. The promise of a bidirectional communication link between the nervous system of humans and computers is compelling, yet important materials challenges must be first addressed to improve the reliability of implantable neural interfaces. This perspective highlights recent progress and challenges related to arguably two of the most common failure modes for implantable neural interfaces: (1) compromised barrier layers and packaging leading to failure of electronic components; (2) encapsulation and rejection of the implant due to injurious tissue-biomaterials interactions, which erode the quality and bandwidth of signals across the biology-technology interface. Innovative materials and device design concepts could address these failure modes to improve device performance and broaden the translational prospects of neural interfaces. A brief overview of contemporary neural interfaces is presented and followed by recent progress in chemistry, materials, and fabrication techniques to improve

Identifiers

PMID34690420
PMCPMC8536148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.