Evidence map›Paper›PMID 34690221›Full record

ArticleJournal of atherosclerosis and thrombosis2022

Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification.

Namuun Ganbaatar, Aya Kadota, Takashi Hisamatsu, Shin-Ichi Araki, Shinji Kume, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Hiroyoshi Segawa and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Observational
  7. Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease.Journal of the American Heart Association · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Namuun GanbaatarNCD Epidemiology Research Center, Shiga University of Medical Science.
Aya KadotaNCD Epidemiology Research Center, Shiga University of Medical Science.
Takashi HisamatsuNCD Epidemiology Research Center, Shiga University of Medical Science.
Shin-Ichi ArakiDepartment of Medicine, Shiga University of Medical Science.
Shinji KumeDepartment of Medicine, Shiga University of Medical Science.
Akira FujiyoshiNCD Epidemiology Research Center, Shiga University of Medical Science.
Sayaka KadowakiNCD Epidemiology Research Center, Shiga University of Medical Science.
Sayuki ToriiNCD Epidemiology Research Center, Shiga University of Medical Science.
Keiko KondoNCD Epidemiology Research Center, Shiga University of Medical Science.
Hiroyoshi SegawaNCD Epidemiology Research Center, Shiga University of Medical Science.
Ebtehal SalmanNCD Epidemiology Research Center, Shiga University of Medical Science.
Itsuko MiyazawaDepartment of Medicine, Shiga University of Medical Science.
Takashi YamamotoDepartment of Medicine, Shiga University of Medical Science.
Yoshihisa NakagawaDepartment of Medicine, Shiga University of Medical Science.
Hiroshi MaegawaDepartment of Medicine, Shiga University of Medical Science.
Katsuyuki MiuraNCD Epidemiology Research Center, Shiga University of Medical Science.
Hirotsugu UeshimaNCD Epidemiology Research Center, Shiga University of Medical Science.
Shiga University of Medical Science · JPOkayama University · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe roles of urinary albumin, eGFRcystatin (eGFRcys), and eGFRcreatinine (eGFRcre) in the progression of coronary artery calcification (CAC) remain unclear. Therefore, the present study investigated the relationship between kidney function and CAC progression.

methodsA total of 760 Japanese men aged 40-79 years were enrolled in this population-based study. Kidney function was measured using eGFRcre, eGFRcys, and the urine albumin-to-creatinine ratio. CAC scores were calculated using the Agatston method. CAC progression was defined as an annual increase of >10 Agatston units (AU) among men with 0<CAC<100 AU at baseline, that of >10% among those with CAC ≥ 100 AU, and any progression for those with CAC=0 at baseline. The relative risk (RR) of CAC progression based on kidney function was assessed using a robust Poisson regression model.

resultsThe mean follow-up period was 4.9 years. CAC progression was detected in 45.8% of participants. Positive associations between CAC progression and albuminuria (>30mg/g) (RR: 1.29; 1.09 to 1.53; p=0.004) and low eGFRcys (<60ml/min/1.73m

conclusionCAC progression was associated with albuminuria; however, its relationship with eGFRcys was weakened by adjustments for risk factors.

Indexed as

AtherosclerosisCoronary Artery DiseaseVascular CalcificationAlbuminsAlbuminuriaDisease ProgressionGlomerular Filtration RateHumansKidneyMaleRisk FactorsAlbuminsCoronary artery calcification progressionEstimated glomerular filtration rateUrinary albumin

Identifiers

PMID34690221
PMCPMC9444674
OpenAlexW3210095352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.