Evidence map›Paper›PMID 34690214›Full record

ArticleThe Journal of reproduction and development2022

Exosomes derived from placental trophoblast cells regulate endometrial epithelial receptivity in dairy cows during pregnancy.

Yue Su, Qianru Li, Qiaochu Zhang, Zhiming Li, Xinxin Yao, Yong Guo, Longfei Xiao, Xiangguo Wang, Hemin Ni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yue SuAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Qianru LiAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Qiaochu ZhangAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Zhiming LiAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Xinxin YaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Yong GuoAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Longfei XiaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Xiangguo WangAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Hemin NiAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Beijing University of Agriculture · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inadequate fetomaternal interactions could directly lead to pregnancy failure in dairy cows. Exosomes are widely involved in endometrial matrix remodeling, immune function changes, placental development, and other processes of embryo implantation and pregnancy in dairy cows. However, the role of exosomes derived from placental trophoblast cells in regulating the receptivity of endometrial cells and facilitating fetomaternal interaction remains unclear. In this study, bovine trophoblast cells (BTCs) were obtained from bovine placenta and immortalized by transfection with telomerase reverse transcriptase (TERT). Immortalized BTCs still possess the basic and key properties of primary BTCs without exhibiting any neoplastic transformation signs. Subsequently, the effect of trophoblast-derived exosomes (TDEs) on endometrial receptivity in endometrial epithelial cells (EECs) was determined, and the mechanism whereby TDEs and their proteins participate in the fetomaternal interaction during bovine pregnancy were explored. EECs were co-cultured with the exosomes derived from BTCs treated with progesterone (P4). Such treatment enhanced the expression of the endometrial receptivity factors, integrin αv, β3, Wnt7a, and MUC1 by changing the extracellular environment, metabolism, and redox balance in EECs via proteome alignment, compared with no treatment according to the DIA quantitation analysis. Our study demonstrated that trophoblast-derived exosome proteins are one of the most critical elements in fetomaternal interaction, and their changes may act as a key signal in altering endometrial receptivity and provide a potential target for improving fertility.

Indexed as

ExosomesTrophoblastsAnimalsCattleEmbryo ImplantationEndometriumEpithelial CellsFemalePlacentaPregnancyDairy cowsEarly pregnancyEndometrial receptivityExosomesTrophoblast

Identifiers

PMID34690214
PMCPMC8872746
OpenAlexW3209039787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.