Evidence map›Paper›PMID 34690147›Full record

ArticleJournal of Alzheimer's disease : JAD2021

COVID-19 Case Fatality and Alzheimer's Disease.

Qiang Zhang, Jordan L Schultz, Georgina M Aldridge, Jacob E Simmering, Youngcho Kim, Amy C Ogilvie, Nandakumar S Narayanan

Registry-linked trialAbstract readLetter
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06984757 (Mid-frontal Delta/Theta and Cognitive Control), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06984757 naenrolling by invitationnot on this map

Mid-frontal Delta/Theta and Cognitive Control

TypeinterventionalSponsorNandakumar NarayananRan2017 to 2029Enrolled635ConditionsParkinson&Amp, Amp, #39, s Disease (PD)ArmsDeep-brain Stimulation, Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Parkinson's disease and COVID-19: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  2. Article
  3. Neurological complications caused by SARS-CoV-2.Clinical microbiology reviews · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. SARS-CoV-2 and neurodegenerative diseases: what we know and what we don't.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiang ZhangDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Jordan L SchultzDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Georgina M AldridgeDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Jacob E SimmeringDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Youngcho KimDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Amy C OgilvieDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Nandakumar S NarayananDepartment of Neurology, University of Iowa, Iowa City, IA, USA.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI PATRICK T O'SHAUGHNESSY · 1990 to 2026
$40.5M
Mid-frontal delta/theta rhythms and cognitive control in PDR01NS100849 · NINDS · UNIVERSITY OF IOWA · PI JAMES F CAVANAGH, Nandakumar Narayanan · 2017 to 2026
$3.6M
Cortical Mechanisms in Lewy Body DementiaK08NS109287 · NINDS · UNIVERSITY OF IOWA · PI ALDRIDGE, GEORGINA · 2018 to 2022
$938k
Investigating Autonomic Dysfunction as an Early Pathologic Feature of Huntington’s DiseaseK23NS117736 · NINDS · UNIVERSITY OF IOWA · PI SCHULTZ, JORDAN · 2021 to 2025
$895k
Carver College of Medicine Clinical Neuroscientist Training Program (CNS-TP)R25NS079173 · NINDS · UNIVERSITY OF IOWA · PI RICHERSON, GEORGE B · 2012 to 2023
$805k
NIEHS NIH HHS P30 ES005605NINDS NIH HHS K08 NS109287NINDS NIH HHS K23 NS117736NINDS NIH HHS R01 NS100849NINDS NIH HHS R25 NS079173
6 · The paper itself

Abstract

Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. After adjusting for demographics and comorbidities, we found that AD patients had higher odds of dying from COVID-19 compared to patients without AD (Odds Ratio: 1.20, 95%confidence interval: 1.09-1.32, p < 0.001). Interestingly, we did not observe increased mortality from COVID-19 among patients with vascular dementia. These data are relevant to the evolving COVID-19 pandemic.

Indexed as

Alzheimer DiseaseCOVID-19Dementia, VascularHumansRetrospective StudiesRisk FactorsAlzheimer’s diseasecase fatalityCoronavirus disease 2019 (COVID-19)dementia with Lewy bodiesfrontotemporal dementiaSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2)vascular dementia

Identifiers

PMID34690147
PMCPMC8841099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.