ArticleJournal of Alzheimer's disease : JAD2021
Associations Between Brain Volumes and Cognitive Tests with Hypertensive Burden in UK Biobank.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cross-organ MRI to assess the relationship between cardiac traits and cerebral white matter hyperintensity volumes.Communications medicine · 2026Article
- No Evidence of Interaction Between FADS2 Genotype and Breastfeeding on Cognitive or Other Traits in the UK Biobank.Behavior genetics · 2025Article
- Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank.Sensors (Basel, Switzerland) · 2025Article
- Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.HGG advances · 2025Article
- The Influence of Birth Weight, Socio-Economic Status, and Adult Health on Brain Volumes during Ageing.Neuroepidemiology · 2025Article
- Effect of the duration of hypertension on white matter structure and its link with cognition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population.BMC nephrology · 2024Article
- "Association of blood cell indices and anemia with risk of incident dementia": Missing important covariates in MRI analysis may be misleading.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability.Genes, brain, and behavior · 2023Article
- Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging.Brain communications · 2023Article
- Effects of Higher Normal Blood Pressure on Brain Are Detectable before Middle-Age and Differ by Sex.Journal of clinical medicine · 2022Article
- Understanding the inter-relationships of type 2 diabetes and hypertension with brain and cognitive health: A UK Biobank study.Diabetes, obesity & metabolism · 2022Article
- The relationship between isolated hypertension with brain volumes in UK Biobank.Brain and behavior · 2022Article
- Aberrant Spontaneous Brain Activity in Coronary Heart Disease Using Fractional Amplitude of Low-Frequency Fluctuations: A Preliminary Resting-State Functional MRI Study.Disease markers · 2022Article
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8 authors.
Funding
Abstract
backgroundMid-life hypertension is an established risk factor for cognitive impairment and dementia and related to greater brain atrophy and poorer cognitive performance. Previous studies often have small sample sizes from older populations that lack utilizing multiple measures to define hypertension such as blood pressure, self-report information, and medication use; furthermore, the impact of the duration of hypertension is less extensively studied.
objectiveTo investigate the relationship between hypertension defined using multiple measures and length of hypertension with brain measure and cognition.
methodsUsing participants from the UK Biobank MRI visit with blood pressure measurements (n = 31,513), we examined the cross-sectional relationships between hypertension and duration of hypertension with brain volumes and cognitive tests using generalized linear models adjusted for confounding.
resultsCompared with normotensives, hypertensive participants had smaller brain volumes, larger white matter hyperintensities (WMH), and poorer performance on cognitive tests. For total brain, total grey, and hippocampal volumes, those with greatest duration of hypertension had the smallest brain volumes and the largest WMH, ventricular cerebrospinal fluid volumes. For other subcortical and white matter microstructural regions, there was no clear relationship. There were no significant associations between duration of hypertension and cognitive tests.
conclusionOur results show hypertension is associated with poorer brain and cognitive health however, the impact of duration since diagnosis warrants further investigation. This work adds further insights by using multiple measures defining hypertension and analysis on duration of hypertension which is a substantial advance on prior analyses-particularly those in UK Biobank which present otherwise similar analyses on smaller subsets.
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