Evidence map›Paper›PMID 34690132›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2021

Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports.

Domenico De Berardis, Michele Fornaro, Antonio Ventriglio, Alessandro Valchera, Federica Vellante, Mauro Pettorruso, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Domenico De BerardisNational Health Service, Department of Mental Health, Psychiatric Service for Diagnosis and Treatment, Hospital "G. Mazzini", Teramo, Italy.ORCID https://orcid.org/0000-0003-4415-5058
Michele FornaroDepartment of Psychiatry, Federico II University, Naples, Italy.ORCID https://orcid.org/0000-0002-9647-0853
Antonio VentriglioDepartment of Psychiatry, University of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0002-3934-7007
Alessandro Valchera"Villa S. Giuseppe" Clinic, Hermanas Hospitalarias, Ascoli Piceno, Italy.
Federica VellanteDepartment of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.ORCID https://orcid.org/0000-0002-4844-5688
Mauro PettorrusoDepartment of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.ORCID https://orcid.org/0000-0002-4164-3040
Giovanni MartinottiDepartment of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.ORCID https://orcid.org/0000-0002-7292-2341
Silvia FraticelliDepartment of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.
Massimo Di GiannantonioDepartment of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.ORCID https://orcid.org/0000-0001-9681-8058
University of Chieti-Pescara · ITFederico II University Hospital · ITOspedale San Giuseppe · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended-release trazodone TRZ Contramid

Indexed as

Add-onCOVID-19Healthcare workersPTSDSerotonin uptake inhibitorsTrazodone

Identifiers

PMID34690132
PMCPMC8553539
OpenAlexW3209768566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.