Evidence map›Paper›PMID 34689763›Full record

ArticleJournal of nanobiotechnology2021

An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors.

Minghua Li, Xiaolong Gao, Chao Lin, Aijun Shen, Jing Luo, Qiongqiong Ji, Jiaqi Wu, Peijun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review.International journal of molecular sciences · 2023
    Review
  9. Menthol: An underestimated anticancer agent.Frontiers in pharmacology · 2023
    Review
  10. Article
  11. Review
  12. Phase-change materials-based platforms for biomedicine.Frontiers in bioengineering and biotechnology · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Minghua LiDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Xiaolong GaoDepartment of Radiology, Luodian Hospital, Baoshan District, Shanghai, 201908, People's Republic of China.
Chao LinInstitute for Translational Medicine, Shanghai East Hospital, Institute for Biomedical Engineering and Nanoscience, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Aijun ShenDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Jing LuoDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Qiongqiong JiDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Jiaqi WuDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Peijun WangDepartment of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China. wangpeijuntjyy@sina.com.
Tongji University · CNTongji Hospital · CNShanghai East Hospital · CN

Funding

Key Discipline Construction Project of the Three-year Action Plan of Shanghai Public Health System GWV-10.1-XK9Scientific and Innovative Action Plan of Shanghai 21ZR1458400
6 · The paper itself

Abstract

Macrophage cell membrane-camouflaged nanocarriers can effectively reduce immune cell clearance and actively target tumors. In this study, a macrophage cell membrane-camouflaged mesoporous silica nanorod (MSNR)-based antitumor drug carrier equipped with a cationic polymer layer was developed. As drug carriers, these MSNRs were loaded with the thermosensitive phase change material L-menthol (LM), the chemotherapy drug doxorubicin (DOX) and the fluorescent molecule indocyanine green (ICG). The rod-like shape of the MSNRs was shown to enhance the penetration of the drug carriers to tumors. In the weakly acidic tumor microenvironment, the cationic polymer exhibited a proton sponge effect to trigger macrophage cell membrane coating detachment, promoting tumor cell uptake. Following nanocarrier uptake, ICG is heated by near-infrared (NIR) irradiation to make LM undergo a phase transition to release DOX and generate a synergistic effect of thermochemotherapy which kills tumor cells and inhibits tumor growth together with reactive oxygen species (ROS) produced by ICG. Overall, this nanohybrid drug delivery system demonstrates an intelligent cascade response, leads to tissue-cell specific targeting and improves drug release accuracy, thus proving to be an effective cancer therapy.

Indexed as

Antineoplastic AgentsCell MembraneCell Line, TumorCell SurvivalDoxorubicinDrug Delivery SystemsHumansIndocyanine GreenInfrared RaysMacrophagesNanotubesNeoplasmsPhotochemotherapyPhotothermal TherapySiliconAntineoplastic AgentsDoxorubicinIndocyanine GreenSiliconDrug deliveryMacrophage cell membraneMesoporous silicon nanorodsPrecision tumor therapy

Identifiers

PMID34689763
PMCPMC8543955
OpenAlexW3209676533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.