Evidence map›Paper›PMID 34689683›Full record

ArticlePharmaceutical biology2021

Simultaneous measurement of tadehaginoside and its principal metabolite in rats by HPLC-MS/MS and its application in pharmacokinetics and tissue distribution study.

Cai-Yun Zhang, Ya-Ting Lu, Yin-Feng Tan, Qi-Bing Liu, Lin Dong, Ning Ma, Wei-Ying Lu, Zhi-Heng Su, Xiao-Po Zhang

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cai-Yun ZhangKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, P. R. China.
Ya-Ting LuPharmaceutical College, Guangxi Medical University, Nanning, China.
Yin-Feng TanKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, P. R. China.
Qi-Bing LiuKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, P. R. China.
Lin DongKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, P. R. China.
Ning MaReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Wei-Ying LuReproductive Medical Center, Hainan Women and Children's Medical Center, Haikou, China.
Zhi-Heng SuPharmaceutical College, Guangxi Medical University, Nanning, China.ORCID 0000-0002-3908-3208
Xiao-Po ZhangKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, P. R. China.
Hainan Medical University · CNGuangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTadehaginoside, an active ingredient isolated from

objectiveTo clarify the metabolism of tadehaginoside MATERIALS AND

methodsThe pharmacokinetics and tissue distribution of tadehaginoside and its metabolite

resultsThe linearity, accuracy, precision, stability, recovery and matrix effect of the method were well-validated and the results satisfied the requirements of biological sample measurement. Treatment with tadehaginoside DISCUSSION AND

conclusionThese results could provide clues for exploring the bioactivity of tadehaginoside based on its pharmacokinetic characteristics.

Indexed as

AnimalsChromatography, High Pressure LiquidCoumaric AcidsGlucosidesMaleRatsRats, Sprague-DawleyReproducibility of ResultsTandem Mass SpectrometryTissue DistributionCoumaric AcidsGlucosidestadehaginosidemetabolic profilemethod development and validationp-Hydroxycinnamic

Identifiers

PMID34689683
PMCPMC8547841
OpenAlexW3120625362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.