ArticleHypertension (Dallas, Tex. : 1979)2022
Systolic Blood Pressure and Mortality in Community-Dwelling Older Adults: Frailty as an Effect Modifier.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Association of Drug-Disease Interactions with Mortality or Readmission in Hospitalised Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis.Drugs - real world outcomes · 2024Pooled it
- Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: an individual patient data meta-analysis.Journal of hypertension · 2022Pooled it
- Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial.BMC medicine · 2025Trial
- Effect of an 18-month meditation training on cardiovascular risk in older adults: a secondary analysis of the Age-Well randomized controlled trial.BMC geriatrics · 2024Trial
- Tai Chi versus health education as a frailty intervention for community-dwelling older adults with hypertension.Aging clinical and experimental research · 2023Trial
- Orthostatic blood pressure disorders in older adults: clinical phenotypes, diagnostic challenges, and cognitive and functional implications.Journal of geriatric cardiology : JGC · 2026Article
- Frailty and blood pressure in older adults: rethinking risk and treatment strategies.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The Effect Modification of Systolic Blood Pressure on the Association of Frailty and Cardiovascular Disease in Community-Dwelling Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Risk of falls and syncope across frailty levels in hypertensive older adults: a longitudinal study.GeroScience · 2026Article
- Article
- Frailty and Cardiovascular Risk.European cardiology · 2026Review
- Prediction of Mortality in Iranian Elderly Using Frailty Index.Journal of caring sciences · 2025Article
- Impact of the RETREAT-FRAIL randomized controlled trial on the antihypertensive treatment in old frail patients.European geriatric medicine · 2025Article
- The relationship between Oxidation Balance Score and all-cause mortality in patients with hypertension: An observational study.Medicine · 2025Observational
- Hypertension and orthostatic hypertension in 85-year-olds and associations with mortality and cognitive decline in a longitudinal cohort study.Scientific reports · 2025Article
- Body mass index and sarcopenia and mortality risk among older hypertensive outpatients; the Nambu Cohort Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Baseline and 7-Year longitudinal trajectories of systolic blood pressure and all-cause mortality in the elderly: A large prospective cohort study in China, 2017-2023.AIMS public health · 2025Article
- U-shaped association between blood pressure and all-cause mortality in older adults: the Shizuoka study.Journal of human hypertension · 2025Article
- Sarcopenia as a risk factor for hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Relationship between changes in late-life blood pressure and the risk of frailty and mortality among older population in China: a cohort study based on CLHLS.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current evidence is insufficient to support different hypertension treatment targets in older adults. We evaluated whether frailty modifies the association between systolic blood pressure (SBP) and 8-year all-cause mortality in community-dwelling older adults. Longitudinal data from the ActiFE Ulm study (Activity and Function in the Elderly in Ulm; Germany) was collected. The association between SBP and mortality was analyzed using Cox proportional hazards models adjusted for age, sex, education, smoking, alcohol consumption, sleep disturbance, diastolic blood pressure, and antihypertensive medications, evaluating the presence of effect modification by frailty according to a frailty index based on the accumulation of deficits. Among 1170 participants (median age 73.9 years, 41.6% women), the prevalence of history of hypertension was 53.8% (median SBP, 144.0 mm Hg [interquartile range, 135.0-149.5], median diastolic blood pressure 78.0 mm Hg [interquartile range, 71.0-86.5]). The median follow-up time was 8.1 years, detecting 268 deaths. We identified 251 (21.5%, 114 deaths) frail participants (frailty index ≥0.2). Effect modification by frailty was detected. Among non-frail a J-shaped association was found with hazard ratio, 4.01 (95% CI, 1.13-14.28) for SBP<110 mm Hg, hazard ratio, 0.92 (95% CI, 0.53-1.59) for SBP 140-150 mm Hg, and hazard ratio, 1.98 (95% CI, 0.75-5.27) for SBP≥160 mm Hg. For frail older adults, a tendency toward lower risk among those with SBP≥130 mm Hg was observed. Our results suggest the presence of effect modification by frailty indicating a possible protective effect for elevated SBP in frail older adults with respect to all-cause mortality even after adjusting for diastolic blood pressure and antihypertensive treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.