Evidence map›Paper›PMID 34689576›Full record

ArticleCell transplantation

Exosomal miR-1275 Secreted by Prostate Cancer Cells Modulates Osteoblast Proliferation and Activity by Targeting the SIRT2/RUNX2 Cascade.

Zihao Zou, Ranran Dai, Nan Deng, Wei Su, Ping Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zihao ZouDepartment of urology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.ORCID 0000-0001-6429-2397
Ranran DaiDepartment of urology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Nan DengDepartment of urology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Wei SuDepartment of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China.
Ping LiuDepartment of urology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Third Affiliated Hospital of Guangzhou Medical University · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is one of the most frequently diagnosed malignancies and the second leading cause of cancer mortality among men worldwide. Modulation of osteoblast activity is involved in PCa metastasis, and miR-1275 is also reported to regulate PCa metastasis; however, the association between cancer-derived exosomal miR-1275 and osteoblast activity is unclear. Here, we isolated exosomes from PC3-derived conditioned medium by ultracentrifugation. We found that miR-1275 could be transferred from PCa cells to osteoblasts via exosomes. Exosomal miR-1275 significantly accelerated the proliferation of osteoblasts and the expression levels of osteoblast-specific genes, such as osteocalcin (OCN), type I collagen (COL-1), and osteopontin (OPN). Moreover, exosomal miR-1275 increased the expression of RUNX2, a master modulator of osteoblast activity, by down-regulation of SIRT2, which in turn influenced the growth and activity of osteoblasts. Our findings indicate that PCa-derived exosomal miR-1275 promotes the proliferation and activity of osteoblasts via modulation of SIRT2/Runx2 signaling.

Indexed as

Cell ProliferationExosomesHumansMaleMicroRNAsOsteoblastsProstatic NeoplasmsSirtuin 2TransfectionMicroRNAsMIRN1275 microRNA, humanSirtuin 2exosomesmiR-1275osteoblast proliferationprostate cancerSIRT2

Identifiers

PMID34689576
PMCPMC8549474
OpenAlexW3211331974

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.