Evidence map›Paper›PMID 34689442›Full record

ArticleJournal of biomedical optics2021

Classification of imbalanced oral cancer image data from high-risk population.

Bofan Song, Shaobai Li, Sumsum Sunny, Keerthi Gurushanth, Pramila Mendonca, Nirza Mukhia, Sanjana Patrick, Shubha Gurudath, Subhashini Raghavan, Imchen Tsusennaro and 13 more

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. Application of artificial intelligence in oral potentially malignant disorders: current opinions and future barriers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Bofan SongThe University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.
Shaobai LiThe University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.
Sumsum SunnyMazumdar Shaw Medical Centre, Bangalore, India.
Keerthi GurushanthKLE Society Institute of Dental Sciences, Bangalore, India.
Pramila MendoncaMazumdar Shaw Medical Foundation, Bangalore, India.
Nirza MukhiaKLE Society Institute of Dental Sciences, Bangalore, India.
Sanjana PatrickBiocon Foundation, Bangalore, India.
Shubha GurudathKLE Society Institute of Dental Sciences, Bangalore, India.
Subhashini RaghavanKLE Society Institute of Dental Sciences, Bangalore, India.
Imchen TsusennaroChristian Institute of Health Sciences and Research, Dimapur, India.
Shirley T LeivonChristian Institute of Health Sciences and Research, Dimapur, India.
Trupti KolurMazumdar Shaw Medical Foundation, Bangalore, India.
Vivek ShettyMazumdar Shaw Medical Foundation, Bangalore, India.
Vidya BushanMazumdar Shaw Medical Foundation, Bangalore, India.
Rohan RameshChristian Institute of Health Sciences and Research, Dimapur, India.
Tyler PetersonThe University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.
Vijay PillaiMazumdar Shaw Medical Foundation, Bangalore, India.
Petra Wilder-SmithUniversity of California Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Alben SigamaniMazumdar Shaw Medical Foundation, Bangalore, India.
Amritha SureshMazumdar Shaw Medical Centre, Bangalore, India.
Moni Abraham KuriakoseCochin Cancer Research Center, Kochi, India.
Praveen BirurKLE Society Institute of Dental Sciences, Bangalore, India.
Rongguang LiangThe University of Arizona, Wyant College of Optical Sciences, Tucson, Arizona, United States.

Funding

Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource SettingR01DE030682 · NIDCR · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2021 to 2025
$2.8M
Low-cost Mobile Oral Cancer Screening for Low Resource SettingUH3CA239682 · NCI · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2018 to 2020
$2.5M
Low-cost Mobile Oral Cancer Screening for Low Resource SettingUH2EB022623 · NIBIB · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2016 to 2017
$996k
NCI NIH HHS UH3 CA239682NIBIB NIH HHS UH2 EB022623NIDCR NIH HHS R01 DE030682
6 · The paper itself

Abstract

significanceEarly detection of oral cancer is vital for high-risk patients, and machine learning-based automatic classification is ideal for disease screening. However, current datasets collected from high-risk populations are unbalanced and often have detrimental effects on the performance of classification.

aimTo reduce the class bias caused by data imbalance. APPROACH: We collected 3851 polarized white light cheek mucosa images using our customized oral cancer screening device. We use weight balancing, data augmentation, undersampling, focal loss, and ensemble methods to improve the neural network performance of oral cancer image classification with the imbalanced multi-class datasets captured from high-risk populations during oral cancer screening in low-resource settings.

resultsBy applying both data-level and algorithm-level approaches to the deep learning training process, the performance of the minority classes, which were difficult to distinguish at the beginning, has been improved. The accuracy of "premalignancy" class is also increased, which is ideal for screening applications.

conclusionsExperimental results show that the class bias induced by imbalanced oral cancer image datasets could be reduced using both data- and algorithm-level methods. Our study may provide an important basis for helping understand the influence of unbalanced datasets on oral cancer deep learning classifiers and how to mitigate.

Indexed as

Mouth NeoplasmsNeural Networks, ComputerAlgorithmsEarly Detection of CancerHumansMachine Learningdeep learningensemble learningimbalanced multi-class datasetsmobile screening deviceoral cancer

Identifiers

PMID34689442
PMCPMC8536945

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.