ReviewJournal of clinical laboratory analysis2021
The diagnostic protocol for hereditary spherocytosis-2021 update.
Review in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 87 citations in OpenAlex.
- Pharmacological readthrough and base editing forMolecular therapy. Nucleic acids · 2026Article
- Decoding the Ektacytometric Landscape of Hereditary Spherocytosis: Insights from 204 Cases.Diagnostics (Basel, Switzerland) · 2026Article
- Case Report: Coexisting Hereditary Spherocytosis, Limited Cutaneous Systemic Sclerosis, and Antiphospholipid Syndrome: A Rare Autoimmune-Hemolytic Association.International journal of rheumatic diseases · 2026Article
- Retrospective evaluation of anatomical laparoscopic single-port partial splenectomy guided by three-dimensional CT reconstruction planning for hereditary spherocytosis.Surgical endoscopy · 2026Article
- Curing the “Incurable”: First Successful Hematopoietic Stem Cell Transplantation in Severe Hereditary Spherocytosis with HomozygousTurkish journal of haematology : official journal of Turkish Society of Haematology · 2026Article
- Expanding the genetic spectrum of hereditary spherocytosis: novel mutations and phenotypic heterogeneity from a 55-patient cohort.Annals of hematology · 2026Article
- De novo mutations in ANK1 and SPTB cause hereditary spherocytosis: three case reports and literature review.Annals of hematology · 2026Review
- Expert Consensus on the Diagnosis and Management of Inherited Hyperbilirubinemia (2025).Journal of clinical and translational hepatology · 2026Article
- From Splenectomy to Partial Splenic Embolization, Which is Better for Hereditary Spherocytosis?Journal of blood medicine · 2026Review
- Expanding the genetic landscape ofFrontiers in genetics · 2026Article
- Case Report: Clinical and genetic analysis of a family with hereditary spherocytosis combined with familial chylomicronemia syndrome.Frontiers in genetics · 2026Article
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- Low Hemoglobin A1c (HbA1c) Revealing Hemolytic Anemia in a Growth Hormone-Treated Child: A Case Report.Cureus · 2025Article
- [Expert consensus on the diagnosis and therapy of inherited hyperbilirubinemia (version 2025)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Article
- Neonatal hereditary spherocytosis: a case report.Italian journal of pediatrics · 2025Article
- Understanding the genetic architecture and phenotypic landscape of SPTB gene variants causing hereditary spherocytosis in an Indian cohort.Human genetics · 2025Article
- Neonatal Hemolytic Jaundice: Causes, Diagnostic Approach, and Management.Children (Basel, Switzerland) · 2025Review
- Two Variants of theBiomedicines · 2025Article
- Case Report: Identification and functional characterization of a novel heterozygous splice-donor (c.647+1G>A) site mutation in theFrontiers in genetics · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHereditary spherocytosis (HS), a commonly encountered hereditary hemolytic disease, is mostly inherited in an autosomal dominant manner. The clinical manifestations in patients with HS show obvious heterogeneity. Moreover, the sensitivity or specificity of some HS diagnostic tests are not ideal and may easily result in misdiagnosis or missed diagnosis in some patients. The objective of this study was to propose a simple and practical diagnostic protocol, which can contribute to the diagnosis of HS and its differential diagnosis with different types of hemolytic anemia such as thalassemia (THAL), autoimmune hemolytic anemia (AIHA), and glucose-6-phosphate dehydrogenase (G6PD) deficiency, thus, to provide an alternative simple and reliable method for better clinical diagnosis of HS.
methodsThrough combing our research with existing experimental technologies and studies, we propose a simple and practical protocol for HS diagnosis, which will help clinicians to improve HS diagnosis.
resultsCompared with the existing HS diagnostic protocols, the HS diagnostic protocol we proposed is simpler. In this new protocol, some experimental tests with ideal diagnostic efficiency are added, such as mean reticulocyte volume (MRV), mean sphered cell volume (MSCV), mean corpuscular volume (MCV), in combination with the observation of clinical manifestations, family investigation, routine tests for hemolytic anemia, genetic testing, and other screening tests.
conclusionThe HS diagnostic protocol we proposed could improve the clinical practice and efficiency of HS diagnosis.
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