ArticleTranslational psychiatry2021
Default-mode and fronto-parietal network connectivity during rest distinguishes asymptomatic patients with bipolar disorder and major depressive disorder.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies.Brain imaging and behavior · 2022Pooled it
- Modulation of resting-state networks following repetitive transcranial alternating current stimulation of the dorsolateral prefrontal cortex.Brain structure & function · 2023Trial
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
- Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Exploring the Role of the Rich Club in Network Control of Neurocognitive States.Human brain mapping · 2026Article
- Unraveling spatiotemporal dynamics in transdiagnosis subtypes of major depressive disorder and bipolar disorder: insights from co-activation patterns and treatment response.Molecular psychiatry · 2026Article
- Electromagnetic field stimulation modulates working memory and cortical alpha oscillations in healthy adults.Scientific reports · 2026Article
- Distinct patterns of default mode network functional connectivity between adolescents with bipolar disorder and major depressive disorder.Frontiers in psychiatry · 2026Article
- Group Information Guided Smooth Independent Component Analysis Method for Multi-Subject fMRI Data Analysis.IEEE journal of biomedical and health informatics · 2026Article
- Sex-specific associations of episode type in bipolar I disorder with neuro-metabolic lateralization of the cortico-striatal-cerebellar (CSC) circuit.BMC psychiatry · 2025Article
- Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.Bipolar disorders · 2025Article
- Fronto-Parietal and Language Network Connectivity and Its Association With Gene Expression Profiles in Bipolar Disorder Before and After Treatment.CNS neuroscience & therapeutics · 2025Article
- The role of self-rumination and self-reflection in depressive symptoms among individuals with attention-deficit/hyperactivity disorder traits.Scientific reports · 2025Article
- Resting-state functional connectivity between the frontoparietal network and the default mode network is aberrantly increased in ankylosing spondylitis.BMC musculoskeletal disorders · 2025Article
- The Role of Temperament Traits in Bipolar Disorder: Neuroimaging Study.Depression and anxiety · 2025Article
- Underlying biological mechanisms of emotion dysregulation in bipolar disorder.Frontiers in psychiatry · 2025Review
- Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients.BMC psychiatry · 2024Article
- SMART (Splitting-Merging Assisted Reliable) Independent Component Analysis for Extracting Accurate Brain Functional Networks.Neuroscience bulletin · 2024Article
- Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa.General psychiatry · 2024Article
- Classification of female MDD patients with and without suicidal ideation using resting-state functional magnetic resonance imaging and machine learning.Frontiers in human neuroscience · 2024Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder (BD) is commonly misdiagnosed as major depressive disorder (MDD). This is understandable, as depression often precedes mania and is otherwise indistinguishable in both. It is therefore imperative to identify neural mechanisms that can differentiate the two disorders. Interrogating resting brain neural activity may reveal core distinguishing abnormalities. We adopted an a priori approach, examining three key networks documented in previous mood disorder literature subserving executive function, salience and rumination that may differentiate euthymic BD and MDD patients. Thirty-eight patients with BD, 39 patients with MDD matched for depression severity, and 39 age-gender matched healthy controls, completed resting-state fMRI scans. Seed-based and data-driven Independent Component analyses (ICA) were implemented to examine group differences in resting-state connectivity (pFDR < 0.05). Seed analysis masks were target regions identified from the fronto-parietal (FPN), salience (SN) and default-mode (DMN) networks. Seed-based analyses identified significantly greater connectivity between the subgenual cingulate cortex (DMN) and right dorsolateral prefrontal cortex (FPN) in BD relative to MDD and controls. The ICA analyses also found greater connectivity between the DMN and inferior frontal gyrus, an FPN region in BD relative to MDD. There were also significant group differences across the three networks in both clinical groups relative to controls. Altered DMN-FPN functional connectivity is thought to underlie deficits in the processing, management and regulation of affective stimuli. Our results suggest that connectivity between these networks could potentially distinguish the two disorders and could be a possible trait mechanism in BD persisting even in the absence of symptoms.
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