ArticleNitric oxide : biology and chemistry2021
Tobacco smoke exposure and fractional exhaled nitric oxide levels among U.S. adolescents.
Article in Nitric oxide : biology and chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 15 citations in OpenAlex.
- Clinical characteristics and prognostic factors of pediatric acute eosinophilic pneumonia: an 11-year single-center retrospective cohort study.European journal of pediatrics · 2026Article
- Association of lung health and cardiovascular health (Life's Essential 8).Frontiers in medicine · 2025Article
- Effects of single and combined urinary polycyclic aromatic hydrocarbon effects on lung function in the U.S. adult population.BMC public health · 2024Article
- Tobacco Smoke Exposure and Sleep Duration among U.S. Adolescents.Behavioral sleep medicine · 2024Article
- Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study.International journal of public health · 2023Article
- Association of advanced paternal age with lung function at school age.Respiratory research · 2022Article
- The Effect of Obesity on Fractional Exhaled Nitric Oxide in School-Aged Children.Children (Basel, Switzerland) · 2022Article
- Factors Influencing the Concentration of Exhaled Nitric Oxide (FeNO) in School Children Aged 8-9-Years-Old in Krakow, with High FeNO Values ≥ 20 ppb.Medicina (Kaunas, Lithuania) · 2022Article
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4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFractional exhaled nitric oxide (FeNO) can objectively guide clinical practice in the assessment, diagnosis, and treatment of eosinophilic airway inflammation. FeNO values may be affected by current smoking, but the role of tobacco smoke exposure (TSE) is understudied.
objectiveThis study investigated the associations between biochemically validated and self-reported TSE and FeNO levels among U.S. nonsmoking adolescents without asthma.
methodsNational Health and Nutrition Examination Survey 2007-2012 data were used. TSE was assessed via serum cotinine and self-reported measures. We assessed FeNO continuously and using cutpoints of >35 ppb and >50 ppb to indicate likely eosinophilic inflammation in children and adults, respectively. We conducted linear and logistic regression adjusting for potential covariates.
resultsOverall, 34.0% of adolescents had low cotinine (0.05-2.99 ng/ml), 6.2% had high cotinine (≥3.00 ng/ml), and 11.9% had home TSE. Compared to adolescents with no/minimal cotinine, adolescents with high cotinine were at reduced odds to have FeNO >35 ppb (adjusted odds ratio [aOR] = 0.54, 95%CI = 0.43,0.69). Adolescents with low cotinine had lower FeNO values (β = -2.05, 95%CI = -3.61,-0.49), and were also at decreased odds to have FeNO >35 ppb (aOR = 0.74, 95%CI = 0.66,0.83) and FeNO >50 ppb (aOR = 0.62, 95%CI = 0.53,0.72). Adolescents with home TSE were at reduced odds to have FeNO >50 ppb (aOR = 0.72, 95%CI = 0.57,0.91) than adolescents without home TSE. Adolescents with a higher number of cigarettes/day smoked inside their home were at reduced odds to have FeNO >35 ppb (OR = 0.98, 95%CI = 0.97,0.99) and FeNO >50 ppb (OR = 0.98, 95%CI = 0.96,0.99).
conclusionsTSE was associated with decreased FeNO levels. The addition of TSE may be clinically important when interpreting thresholds for FeNO.
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