ArticleBMC plant biology2021
Identification of GROWTH-REGULATING FACTOR transcription factors in lettuce (Lactuca sativa) genome and functional analysis of LsaGRF5 in leaf size regulation.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 75 citations in OpenAlex.
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- Genome-wide characterization and expression analysis of the growth-regulating factor family in Mikania micrantha.BMC plant biology · 2025Article
- Recent advances in improving yield and immunity through transcription factor engineering.Journal of integrative plant biology · 2025Review
- The Identification and Characterization of theInternational journal of molecular sciences · 2024Article
- Genome‑wide identifcation and expression analysis of growth-regulating factors under drought in Brassica juncea.Scientific reports · 2024Article
- Chia (Salvia hispanica L.), a functional 'superfood': new insights into its botanical, genetic and nutraceutical characteristics.Annals of botany · 2024Review
- Article
- Genome-wide identification and expression profiling of growth‑regulating factor (GRF) and GRF‑interacting factor (GIF) gene families in chickpea and pigeonpea.Scientific reports · 2024Article
- Genome-Wide Identification and Characterization of the GRAS Gene Family in Lettuce Revealed That SilencingPlants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification and Expression Analysis of Growth-Regulating Factors inPlants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification, Characterization, and Expression Analysis of the HD-Zip Gene Family inGenes · 2024Article
- Genome-wide identification of the GRF family in sweet orange (Citrus sinensis) and functional analysis of the CsGRF04 in response to multiple abiotic stresses.BMC genomics · 2024Article
- Editorial: Advances on genomics and genetics of horticultural crops and their contribution to breeding efforts - volume II.Frontiers in plant science · 2024Article
- Genome-wide investigation of WRKY gene family inFrontiers in plant science · 2024Article
- Construction of the first high-density genetic linkage map and QTL mapping of flavonoid and leaf-size related traits in Epimedium.BMC plant biology · 2023Article
- GRF-GIF chimeric proteins enhance in vitro regeneration and Agrobacterium-mediated transformation efficiencies of lettuce (Lactuca spp.).Plant cell reports · 2023Article
- Genome-wide identification and systematic analysis of the HD-Zip gene family and its roles in response to pH in Panax ginseng Meyer.BMC plant biology · 2023Article
- Genome-wide identification, phylogeny, and expression analysis of GRF transcription factors in pineapple (Frontiers in plant science · 2023Article
- Screening of differentially expressed microRNAs and target genes in two potato varieties under nitrogen stress.BMC plant biology · 2022Article
- Fine mapping and characterization of a major QTL for grain weight on wheat chromosome arm 5DL.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGROWTH-REGULATING FACTORs (GRFs), a type of plant-specific transcription factors, play important roles in regulating plant growth and development. Although GRF gene family has been identified in various plant species, a genome-wide analysis of this family in lettuce (Lactuca sativa L.) has not been reported yet.
resultsHere we identified 15 GRF genes in lettuce and performed comprehensive analysis of them, including chromosomal locations, gene structures, and conserved motifs. Through phylogenic analysis, we divided LsaGRFs into six groups. Transactivation assays and subcellular localization of LsaGRF5 showed that this protein is likely to act as a transcriptional factor in the cell nucleus. Furthermore, transgenic lettuce lines overexpressing LsaGRF5 exhibited larger leaves, while smaller leaves were observed in LsaMIR396a overexpression lines, in which LsaGRF5 was down-regulated.
conclusionsThese results in lettuce provide insight into the molecular mechanism of GRF gene family in regulating leaf growth and development and foundational information for genetic improvement of the lettuce variations specialized in leaf character.
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