SynthesisBMC infectious diseases2021
Serum CA-125 for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Disseminated Tuberculosis Mimicking Metastatic Cancer During Ruxolitinib Therapy for Polycythemia Vera: A Case Report and Literature Review.The American journal of case reports · 2026Review
- Identification and functional characterization of glycosyltransferase-related biomarkers for tuberculosis diagnosis.AMB Express · 2025Article
- Promising outcomes of the PD-L1 inhibitor Socazolimab in recurrent and metastatic cervical cancer: a case report.Frontiers in oncology · 2025Article
- A correlation study of serum tumor markers with systemic lupus erythematosus-associated interstitial lung disease.Frontiers in medicine · 2025Article
- Article
- Editorial: Immuno-diagnosis of active tuberculosis; are we making progress?Frontiers in immunology · 2023Article
- Clinical significance of CA-125 in elderly patients with active pulmonary tuberculosis: A retrospective study.Saudi medical journal · 2022Article
- Abdominal Tuberculosis Mimicking Ovarian Cancer: A Case Report and Review of the Literature.International medical case reports journal · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary tuberculosis (PTB) remains the world's deadliest infectious killer. Serum CA-125 test are useful in the diagnosis of PTB. Although studies on the relation between CA-125 and PTB have been reported, the specificity and sensitivity of serum CA-125 in diagnosing PTB vary widely among different studies. The present study was performed to evaluate the accuracy of CA-125 for the diagnosis of PTB via a meta-analysis of data obtained from previous studies.
methodsEnglish and Chinese medical electronic databases were searched for eligible studies published up to February 2020. STATA software was used to obtain a pooled estimation of the diagnostic accuracy of CA-125 and analyze the heterogeneity of the recruited studies. Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to evaluate the quality of the obtained studies.
resultsA total of 16 articles were included in this study. The pooled sensitivity and specificity of CA-125 were 0.85 [95% confidence interval (CI) 0.75-0.91] and 0.87 (95% CI 0.78-0.93), respectively. Moreover, the pooled positive likelihood ratio (LR+), negative likelihood ratio (LR-), and diagnostic odds ratio (DOR) of CA-125 were 6.65 (95% CI 3.62-12.20), 0.18 (95% CI 0.10-0.31), and 37.82 (95% CI 13.17-108.60), respectively. The area under the summary receiver operating characteristic curve (AUC) was 0.93.
conclusionsTaken together, the results indicate that serum CA-125 presents potential practical value for diagnosing PTB, but its clinical applicability must be further examined.
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