Evidence map›Paper›PMID 34688253›Full record

Trial reportThe journal of headache and pain2021

Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.

Shana A B Burrowes, Olga Goloubeva, Michael L Keaser, Jennifer A Haythornthwaite, David A Seminowicz

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of headache and pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02133209 (MRI Outcomes of Mindfulness Meditation for Migraine), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02133209 nacompletednot on this map

MRI Outcomes of Mindfulness Meditation for Migraine

TypeinterventionalSponsorJohns Hopkins UniversityRan2014 to 2018Enrolled98ConditionsMigraineArmsMindfulness Based Stress Reduction, Stress Management for Headaches
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shana A B BurrowesSection of Infectious Diseases, Department of Medicine, Boston University School of Medicine, 02218, Boston, MA, USA. shanab@bu.edu.
Olga GoloubevaGreenebaum Comprehensive Cancer Center, University of Maryland, University of Maryland Baltimore, 21201, Baltimore, MD, USA.
Michael L KeaserDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, 21201, Baltimore, MD, USA.
Jennifer A HaythornthwaiteDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David A SeminowiczDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, 21201, Baltimore, MD, USA.
University of Maryland, Baltimore · USBoston University · USJohns Hopkins Medicine · US

Funding

MRI outcomes of mindfulness meditation for migraineR01AT007176 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI SEMINOWICZ, DAVID · 2013 to 2017
$3.5M
NCCIH NIH HHS AT007176NCCIH NIH HHS R01 AT007176
6 · The paper itself

Abstract

backgroundMigraine sufferers face difficulties getting appropriate care and treatment. Migraine is associated with reduced gray matter volume (GMV) in several brain regions, which could be related to various clinical characteristics of the disorder.

objectivesTo examine differences in GMV in migraine patients with and without prior clinical care for migraine and examine differences in migraine clinical variables, psychosocial symptoms and their relationship with GMV.

methodsWe utilized the baseline MRI scan and psychosocial symptom questionnaires from a longitudinal randomized controlled trial. Prior care of migraine was determined by diagnosis by a medical practitioner or prescription of migraine specific medication.

results117 patients were included in the study. Patients without prior care (n=23) had reduced GMV in the right dorsal medial prefrontal cortex (dMPFC) relative to patients who had prior care (p=0.034, FWE corrected). Both patient groups had reduced GMV compared to healthy controls (n=36). Patient groups did not differ in headache clinical variables. Regardless of care status, increasing scores on the stress (Perceived Stress Score) and depression questionnaires (Patient Health Questionnaire) were associated with increased GMV in the dMPFC.

conclusionsClinical care may impact GMV in migraine patients. Patients may need different treatment options to address this baseline deficit.

trial registrationNCT02133209.

Indexed as

Gray MatterMigraine DisordersBrainCross-Sectional StudiesHumansMagnetic Resonance ImagingDepressionGray matter volumeHeadacheMigraineMRIPrior careStressTreatment naïve

Identifiers

PMID34688253
PMCPMC8542322
OpenAlexW3208662834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.