ArticleCell metabolism2021
Cold exposure protects from neuroinflammation through immunologic reprogramming.
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In one paragraph
Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Cold-water exposure and psychological outcomes in adults: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Temperature extremes and autoimmune diseases.Seminars in immunopathology · 2026Review
- Is cold exposure a viable lifestyle intervention for mental health? Reviewing evidence and mechanisms.Molecular psychiatry · 2026Review
- N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure.Experimental & molecular medicine · 2026Article
- Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression.Signal transduction and targeted therapy · 2026Review
- Inhibition of STING pathway attenuates experimental abdominal aortic aneurysm progression.Acta pharmacologica Sinica · 2026Article
- The PM20D1-OLE pathway induces microglia rewiring to ameliorate Alzheimer disease.Cell death & disease · 2026Article
- Cold exposure and metabolic health: Therapeutic potential for obesity, diabetes, and beyond.Physiological reports · 2026Review
- Cold Exposure Alleviates Colitis via Parallel Integration of Colonic Mucosal Regeneration and Ileal Antimicrobial Defense.Biomedicines · 2026Article
- Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.CNS neuroscience & therapeutics · 2026Article
- Frequency-selective thymic programming by early-life cold stress requires interferon regulatory factor 5.Frontiers in immunology · 2026Article
- Alcohol and substance use in extreme environment temperatures exposures, neural mechanisms, coping mechanisms, substance use disorders, and increased hospital visits.Frontiers in human neuroscience · 2026Review
- ZNF334 truncation mutation drives cold-induced autoinflammation.EMBO molecular medicine · 2025Article
- Glial cell crosstalk in Parkinson's disease: Mechanisms, implications, and therapeutic strategies.Fundamental research · 2025Review
- Metabolic Risk Factors at the Time of Cancer Diagnosis in Primary Care: A Cross-Sectional Study.Cureus · 2025Article
- Developing an IPF Prognostic Model and Screening for Key Genes Based on Cold Exposure-Related Genes Using Bioinformatics Approaches.Biomedicines · 2025Article
- Review
- Integrated effects of cold acclimation: physiological mechanisms, psychological adaptations, and potential applications.Frontiers in physiology · 2025Review
- Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences.International journal of molecular sciences · 2024Review
- Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy.Journal of nanobiotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 2 countries.
Martina SpiljarDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Karin SteinbachDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
Dorothée RigoDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Nicolas Suárez-ZamoranoDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Ingrid WagnerDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
Noushin HadadiDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Ilena VincentiDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
Nicolas PageDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
Bogna KlimekDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
Mary-Aude RochatDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Mario KreutzfeldtDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
Claire ChevalierDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Ozren StojanovićDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Olivia BejuyCIBM Centre for BioMedical Imaging, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
Didier ColinSmall Animal Preclinical Imaging Platform, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
Matthias MackDepartment of Internal Medicine II - Nephrology, University Hospital Regensburg, Regensburg, Germany.
Dilay CanseverInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Melanie GreterInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Doron MerklerDepartment of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland. Electronic address: doron.merkler@unige.ch.
Mirko TrajkovskiDepartment of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: mirko.trajkovski@unige.ch.
University of Geneva · CHUniversity of Zurich · CHCentre d'Imagerie BioMedicale · CHUniversity Hospital of Geneva · CHUniversity Hospital Regensburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6C
Indexed as
Encephalomyelitis, Autoimmune, ExperimentalNeuroinflammatory DiseasesAdoptive TransferAnimalsAutoimmunityMiceMice, Inbred C57BLTh17 Cellsautoimmunitybone marrowcold exposureexperimental autoimmune encephalomyelitisimmunometabolisminflammationmonocytesmultiple sclerosisneuroinflammationT cell priming
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.