ArticleEuropean heart journal. Cardiovascular Imaging2021
The impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- 4D Flow MRI Characterization of Left Atrial Vortical Flow in Atrial Fibrillation Following Catheter Ablation.Journal of imaging · 2026Article
- The "Floating Lotus" Sign on Intracardiac Echocardiography: Characterization and Predictors of a Novel Left Atrial Appendage Pseudo-Thrombus.Reviews in cardiovascular medicine · 2026Article
- Determinants of Impaired Left Atrial Hemodynamics in Paroxysmal Atrial Fibrillation: A 4D Flow MRI Study.Journal of imaging · 2026Article
- Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation.Diagnostics (Basel, Switzerland) · 2026Article
- Severe Aortic Stenosis Is Associated With Left Atrial Prothrombotic Flow That Persists Despite Valve Replacement.Journal of the American Heart Association · 2026Article
- Demographic and cardiovascular risk factors associated with blood flow characteristics of the left atrium and left atrial appendage.European radiology · 2026Observational
- Left atrial appendage blood flow analysis using four-dimensional flow magnetic resonance imaging.General thoracic and cardiovascular surgery · 2026Article
- Widened arterial time-density curves of CTP may identify cardioembolic etiology in acute large-artery occlusion stroke.Neuroradiology · 2026Article
- Prognostic value of left atrial parameters derived from magnetic resonance in dilated cardiomyopathy: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2026Article
- CFD-derived radiomics from hemodynamic maps for quantitative assessment of left atrial flow in atrial fibrillation: a proof-of-concept study.Frontiers in cardiovascular medicine · 2026Article
- Left Atrial Dysfunction in Patients with Atrial Fibrillation and Heart Failure.Current cardiology reports · 2025Review
- Deep phenotyping of left atrial characteristics: sphericity and stiffness stratify patients with atrial fibrillation and cardioembolic stroke.The international journal of cardiovascular imaging · 2025Article
- A novel method for preparing clot analogs under dynamic vortical flow for testing mechanical thrombectomy devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk.Circulation. Genomic and precision medicine · 2025Article
- Atrial Cardiomyopathy in Atrial Fibrillation: A Multimodal Diagnostic Framework.Diagnostics (Basel, Switzerland) · 2025Review
- Fusion of Personalized Federated Learning (PFL) with Differential Privacy (DP) Learning for Diagnosis of Arrhythmia Disease.PloS one · 2025Article
- The correlation between left atrial appendage morphology and thromboembolic risk in atrial fibrillation.Frontiers in stroke · 2025Review
- Radiomics prediction models of left atrial appendage hypercoagulability based on machine learning algorithms: an exploration about cardiac computed tomography angiography imaging.The international journal of cardiovascular imaging · 2024Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
aimsAltered left atrial (LA) blood flow characteristics account for an increase in cardioembolic stroke risk in atrial fibrillation (AF). Here, we aimed to assess whether exposure to stroke risk factors is sufficient to alter LA blood flow even in the presence of sinus rhythm (SR). METHODS AND
resultsWe investigated 95 individuals: 37 patients with persistent AF, who were studied before and after cardioversion [Group 1; median CHA2DS2-VASc = 2.0 (1.5-3.5)]; 35 individuals with no history of AF but similar stroke risk to Group 1 [Group 2; median CHA2DS2-VASc = 3.0 (2.0-4.0)]; and 23 low-risk individuals in SR [Group 3; median CHA2DS2-VASc = 0.0 (0.0-0.0)]. Cardiac function and LA flow characteristics were evaluated using cardiac magnetic resonance. Before cardioversion, Group 1 displayed impaired left ventricular (LV) and LA function, reduced LA flow velocities and vorticity, and a higher normalized vortex volume (all P < 0.001 vs. Groups 2 and 3). After restoration of SR at ≥4-week post-cardioversion, LV systolic function and LA flow parameters improved significantly (all P < 0.001 vs. pre-cardioversion) and were no longer different from those in Group 2. However, in the presence of SR, LA flow peak and mean velocity, and vorticity were lower in Groups 1 and 2 vs. Group 3 (all P < 0.01), and were associated with impaired LA emptying fraction (LAEF) and LV diastolic dysfunction.
conclusionPatients at moderate-to-high stroke risk display altered LA flow characteristics in SR in association with an LA myopathic phenotype and LV diastolic dysfunction, regardless of a history of AF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.