Evidence map›Paper›PMID 34687351›Full record

ArticleArchives of toxicology2022

Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.

Elena V Kozlova, Matthew C Valdez, Maximillian E Denys, Anthony E Bishay, Julia M Krum, Kayhon M Rabbani, Valeria Carrillo, Gwendolyn M Gonzalez, Gregory Lampel, Jasmin D Tran and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  15. Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas.International journal of environmental research and public health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 3 countries.

Elena V KozlovaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.ORCID 0000-0002-4691-6618
Matthew C ValdezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Maximillian E DenysDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Anthony E BishayDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.ORCID 0000-0002-6057-3770
Julia M KrumDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Kayhon M RabbaniDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Valeria CarrilloDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Gwendolyn M GonzalezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Gregory LampelDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Jasmin D TranDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Brigitte M VazquezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Laura M AnchondoDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Syed A UddinDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Nicole M HuffmanDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Eduardo MonarrezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Duraan S OlomiDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Bhuvaneswari D ChinthirlaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA.
Richard E HartmanDepartment of Psychology, Loma Linda University, Loma Linda, CA, 92350, USA.
Prasada Rao S KodavantiNeurological and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, CPHEA/ORD, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, 27711, USA.
Gladys ChompreBiotechnology Department, Pontifical Catholic University of Puerto Rico, Ponce, Puerto Rico, 00717-9997, USA.
Allison L PhillipsDuke University, Nicholas School of the Environment, Durham, NC, 27710, USA.
Heather M StapletonDuke University, Nicholas School of the Environment, Durham, NC, 27710, USA.
Bernhard HenkelmannHelmholtz Zentrum Munchen, Molecular EXposomics (MEX), German National Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, Neuherberg, Munich, Germany.
Karl-Werner SchrammHelmholtz Zentrum Munchen, Molecular EXposomics (MEX), German National Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, Neuherberg, Munich, Germany.ORCID 0000-0002-8945-4062
Margarita C Curras-CollazoDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA. mcur@ucr.edu.ORCID 0000-0002-0189-4179
University of California, Riverside · USDuke University · USHelmholtz Zentrum München · DEEnvironmental Protection Agency · USLoma Linda University · USPontifical Catholic University of Puerto Rico · PR

Funding

The Role of Midbrain to Prelimbic Cortex Glutamatergic projections in Stress-induced Drug SeekingU54MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI Emmanuel Antonio Cruz, Kenira J Thompson · 2019 to 2026
$35.9M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12RR003050 · NCRR · PONCE SCHOOL OF MEDICINE · PI ARMSTRONG, RAUL A · 1985 to 2011
$28.1M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI NOEL, RICHARD J. · 2012 to 2018
$15.9M
UC Riverside MARC U* Star Undergraduate Research ProgramT34GM062756 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MARTINEZ, ERNEST · 2001 to 2022
$8.7M
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
NCRR NIH HHS G12 RR003050NIEHS NIH HHS R01 ES016099NIGMS NIH HHS T34 GM062756NIH HHS NIH R01 ES016099NIH HHS T34GM062756NIMHD NIH HHS G12 MD007579NIMHD NIH HHS U54 MD007579
6 · The paper itself

Abstract

Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse neurodevelopmental effects. PBDEs may act as risk factors for autism spectrum disorders (ASD), characterized by abnormal psychosocial functioning, although direct evidence is currently lacking. Using a translational exposure model, we tested the hypothesis that maternal transfer of a commercial mixture of PBDEs, DE-71, produces ASD-relevant behavioral and neurochemical deficits in female offspring. C57Bl6/N mouse dams (F0) were exposed to DE-71 via oral administration of 0 (VEH/CON), 0.1 (L-DE-71) or 0.4 (H-DE-71) mg/kg bw/d from 3 wk prior to gestation through end of lactation. Mass spectrometry analysis indicated in utero and lactational transfer of PBDEs (in ppb) to F1 female offspring brain tissue at postnatal day (PND) 15 which was reduced by PND 110. Neurobehavioral testing of social novelty preference (SNP) and social recognition memory (SRM) revealed that adult L-DE-71 F1 offspring display deficient short- and long-term SRM, in the absence of reduced sociability, and increased repetitive behavior. These effects were concomitant with reduced olfactory discrimination of social odors. Additionally, L-DE-71 exposure also altered short-term novel object recognition memory but not anxiety or depressive-like behavior. Moreover, F1 L-DE-71 displayed downregulated mRNA transcripts for oxytocin (Oxt) in the bed nucleus of the stria terminalis (BNST) and supraoptic nucleus, and vasopressin (Avp) in the BNST and upregulated Avp1ar in BNST, and Oxtr in the paraventricular nucleus. Our work demonstrates that developmental PBDE exposure produces ASD-relevant neurochemical, olfactory processing and behavioral phenotypes that may result from early neurodevelopmental reprogramming within central social and memory networks.

Indexed as

Autistic DisorderFlame RetardantsNeuropeptidesAnimalsFemaleHalogenated Diphenyl EthersHumansMaternal ExposureMiceMice, Inbred C57BLPhenotypeFlame RetardantsHalogenated Diphenyl EthersNeuropeptidespentabromodiphenyl etherDevelopmental exposureEndocrine-disrupting chemicalsFlame retardantsOxytocinPolybrominated diphenyl ethersVasopressin

Identifiers

PMID34687351
PMCPMC8536480
OpenAlexW3206717380

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.