ArticleClinical research in cardiology : official journal of the German Cardiac Society2022
Initial in-hospital heart rate is associated with long-term survival in patients with acute ischemic stroke.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current exercise-based rehabilitation impacts on poststroke exercise capacity, blood pressure, and lipid control: a meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Integrative Multidimensional Machine Learning Models for Stroke Prognosis: Age-Stratified and History Engineered Perspectives.Diagnostics (Basel, Switzerland) · 2026Article
- Performance of Modified NIHSS and APUA Scores in Predicting in-Hospital Mortality and Functional Outcome in Acute Ischemic Stroke: A Retrospective Cohort Study.Medeniyet medical journal · 2026Article
- Impact of heart rate on eGFR decline in ischemic stroke patients.Clinical kidney journal · 2025Article
- Predictive value of heart rate for prognosis in patients with cerebral infarction without atrial fibrillation comorbidity analyzed according to the MIMIC-IV database.Frontiers in neurology · 2025Article
- Assessment of the impact of resting heart rate on the risk of major adverse cardiovascular events after ischemic stroke: a retrospective observational study.BMC neurology · 2024Observational
- Association between initial in-hospital heart rate and glycemic control in patients with acute ischemic stroke and diabetes mellitus.BMC endocrine disorders · 2023Article
- Development and Validation of a Novel Score for Predicting Long-Term Mortality after an Acute Ischemic Stroke.International journal of environmental research and public health · 2023Article
- Age Stratification in Acute Ischemic Stroke Patients with Heart Failure.Journal of clinical medicine · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
aimsIncreased heart rate has been associated with stroke risk and outcomes. The purpose of this study was to explore the long-term prognostic value of initial in-hospital heart rate in patients with acute ischemic stroke (AIS).
methodsWe analyzed data from 21,655 patients with AIS enrolled (January 2010-September 2018) in the Chang Gung Research Database. Mean initial in-hospital heart rates were averaged and categorized into 10-beat-per-minute (bpm) increments. The primary and secondary outcomes were all-cause mortality and cardiovascular death. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable adjusted Cox proportional hazard models, using the heart rate < 60 bpm subgroup as the reference.
resultsThe adjusted HRs for all-cause mortality were 1.23 (95% CI 1.08-1.41) for heart rate 60-69 bpm, 1.74 (95% CI 1.53-1.97) for heart rate 70-79 bpm, 2.16 (95% CI 1.89-2.46) for heart rate 80-89 bpm, and 2.83 (95% CI 2.46-3.25) for heart rate ≥ 90 bpm compared with the reference group. Likewise, heart rate ≥ 60 bpm was also associated with an increased risk of cardiovascular death (adjusted HR 1.18 [95% CI 0.95-1.46] for heart rate 60-69 bpm, 1.57 [95% CI 1.28-1.93] for heart rate 70-79 bpm, 1.98 [95% CI 1.60-2.45] for heart rate 80-89 bpm, and 2.36 [95% CI 1.89-2.95] for heart rate ≥ 90 bpm).
conclusionsHigh initial in-hospital heart rate is an independent predictor of all-cause mortality and cardiovascular death in patients with AIS.
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