ArticleJournal of applied clinical medical physics2021
The benefit of MR-only radiotherapy treatment planning for anal and rectal cancers: A planning study.
Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A combined automatic organ at risk contouring and synthetic Computed Tomography solution for pelvic Magnetic Resonance-only radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Dose differences between patients treated with MR-only, CT-only, or MR-CT fusion radiotherapy for prostate cancer.The British journal of radiology · 2025Article
- Evaluating the Effect of Co-Registered Diagnostic MR Images Based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer.Journal of biomedical physics & engineering · 2025Article
- Contouring practices and artefact management within a synthetic CT-based radiotherapy workflow for the central nervous system.Radiation oncology (London, England) · 2024Article
- The Role of MRI and PET/CT in Radiotherapy Target Volume Determination in Gastrointestinal Cancers-Review of the Literature.Cancers · 2023Review
- The benefit of MR-only radiotherapy treatment planning for anal and rectal cancers: A planning study.Journal of applied clinical medical physics · 2021Article
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Authors and funding
12 authors.
Funding
Abstract
introductionLimited evidence exists showing the benefit of magnetic resonance (MR)-only radiotherapy treatment planning for anal and rectal cancers. This study aims to assess the impact of MR-only planning on target volumes (TVs) and treatment plan doses to organs at risks (OARs) for anal and rectal cancers versus a computed tomography (CT)-only pathway. MATERIALS AND
methodsForty-six patients (29 rectum and 17 anus) undergoing preoperative or radical external beam radiotherapy received CT and T2 MR simulation. TV and OARs were delineated on CT and MR, and volumetric arc therapy treatment plans were optimized independently (53.2 Gy/28 fractions for anus, 45 Gy/25 fractions for rectum). Further treatment plans assessed gross tumor volume (GTV) dose escalation. Differences in TV volumes and OAR doses, in terms of Vx Gy (organ volume (%) receiving x dose (Gy)), were assessed.
resultsMR GTV and primary planning TV (PTV) volumes systematically reduced by 13 cc and 98 cc (anus) and 44 cc and 109 cc (rectum) respectively compared to CT volumes. Statistically significant OAR dose reductions versus CT were found for bladder and uterus (rectum) and bladder, penile bulb, and genitalia (anus). With GTV boosting, statistically significant dose reductions were found for sigmoid, small bowel, vagina, and penile bulb (rectum) and vagina (anus).
conclusionOur findings provide evidence that the introduction of MR (whether through MR-only or CT-MR pathways) to radiotherapy treatment planning for anal and rectal cancers has the potential to improve treatments. MR-related OAR dose reductions may translate into less treatment-related toxicity for patients or greater ability to dose escalate.
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