Evidence map›Paper›PMID 34687095›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2021

ABO-incompatible kidney transplantation in perspective of deceased donor transplantation and induction strategies: a propensity-matched analysis.

Annelies E de Weerd, Jan A J G van den Brand, Hanneke Bouwsma, Aiko P J de Vries, Ine Ph M M Dooper, Jan-Stephan F Sanders, Maarten H L Christiaans, Franka E van Reekum, Arjan D van Zuilen, Frederike J Bemelman and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. ABO-incompatible kidney transplantation: impact of apheresis on graft and patient survival in recipients with low isoagglutinin titer.Transplant international : official journal of the European Society for Organ Transplantation · 2026
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  16. ABO-Incompatibility: Time to Challenge the Paradigm of Equivalence in Live-Donor Kidney Transplantation?Transplant international : official journal of the European Society for Organ Transplantation · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Annelies E de WeerdDepartment of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jan A J G van den BrandDepartment of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Hanneke BouwsmaDepartment of Nephrology and Leiden Transplant Center, LUMC Leiden University Medical Center, Leiden, The Netherlands.
Aiko P J de VriesDepartment of Nephrology and Leiden Transplant Center, LUMC Leiden University Medical Center, Leiden, The Netherlands.
Ine Ph M M DooperDepartment of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Jan-Stephan F SandersDepartment of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Maarten H L ChristiaansDepartment of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands.
Franka E van ReekumDepartment of Nephrology, Utrecht University Medical Center, Utrecht, The Netherlands.
Arjan D van ZuilenDepartment of Nephrology, Utrecht University Medical Center, Utrecht, The Netherlands.
Frederike J BemelmanDepartment of Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Azam S NurmohamedDepartment of Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Madelon van AgterenDepartment of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Michiel G H BetjesDepartment of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Margriet F C de JongDepartment of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
Marije C BaasDepartment of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Erasmus MC · NLAmsterdam University Medical Centers · NLLeiden University Medical Center · NLRadboud University Medical Center · NLUniversity Medical Center Groningen · NLMaastricht University · NLRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplant candidates are blood group incompatible with roughly one out of three potential living donors. We compared outcomes after ABO-incompatible (ABOi) kidney transplantation with matched ABO-compatible (ABOc) living and deceased donor transplantation and analyzed different induction regimens. We performed a retrospective study with propensity matching and compared patient and death-censored graft survival after ABOi versus ABOc living donor and deceased donor kidney transplantation in a nationwide registry from 2006 till 2019. 296 ABOi were compared with 1184 center and propensity-matched ABOc living donor and 1184 deceased donor recipients (matching: recipient age, sex, blood group, and PRA). Patient survival was better compared with deceased donor [hazard ratio (HR) for death of HR 0.69 (0.49-0.96)] and non-significantly different from ABOc living donor recipients [HR 1.28 (0.90-1.81)]. Rate of graft failure was higher compared with ABOc living donor transplantation [HR 2.63 (1.72-4.01)]. Rejection occurred in 47% of 140 rituximab versus 22% of 50 rituximab/basiliximab, and 4% of 92 alemtuzumab-treated recipients (P < 0.001). ABOi kidney transplantation is superior to deceased donor transplantation. Rejection rate and graft failure are higher compared with matched ABOc living donor transplantation, underscoring the need for further studies into risk stratification and induction therapy [NTR7587, www.trialregister.nl].

Indexed as

Kidney TransplantationABO Blood-Group SystemBlood Group IncompatibilityGraft RejectionGraft SurvivalHumansLiving DonorsRetrospective StudiesABO Blood-Group SystemABO-incompatible kidney transplantationalemtuzumabdeceased donor transplantationliving donor transplantationpatient and graft survivalrejection

Identifiers

PMID34687095
PMCPMC9299000
OpenAlexW3207476567

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.