Evidence map›Paper›PMID 34687072›Full record

ArticleJournal of veterinary internal medicine2021

Clinical, laboratory and ultrasonographic findings differentiating low-grade intestinal T-cell lymphoma from lymphoplasmacytic enteritis in cats.

Valérie Freiche, Julien Fages, Mathieu Victor Paulin, Julie Bruneau, Lucile Couronné, Alexander J German, Dominique Penninck, Olivier Hermine

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Valérie Freiche *Ecole Nationale Vétérinaire d'Alfort, CHUVA, Unité de Médecine Interne, Maisons-Alfort, France.ORCID https://orcid.org/0000-0003-2041-078X
Julien Fages *Centre DMV, Lachine, Quebec, Canada.
Mathieu Victor PaulinDepartment of Small Animal Clinical Sciences, Western College of Veterinary Medicine-University of Saskatchewan, Saskatoon, Saskatchewan, Canada.ORCID https://orcid.org/0000-0001-8358-5101
Julie BruneauPathology Department, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM U1163, Imagine Institute, University of Paris, Paris, France.
Lucile CouronnéCytogenetics Department, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM U1163, Imagine Institute, University of Paris, Paris, France.
Alexander J GermanInstitute of Life Course and Medical Sciences, University of Liverpool, Merseyside, United Kingdom.ORCID https://orcid.org/0000-0002-3017-7988
Dominique PenninckDiagnostic Imaging Section, Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, Grafton, Massachusetts, USA.
Olivier HermineHematology Department, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP); Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, INSERM U1163, Imagine Institute, University of Paris, Paris, France.
Hôpital Necker-Enfants Malades · FRÉcole Nationale Vétérinaire d'Alfort · FRLachine Hospital · CATufts University · USUniversity of Liverpool · GBUniversity of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-grade intestinal T-cell lymphoma (LGITL) is the most common intestinal neoplasm in cats. Differentiating LGITL from lymphoplasmacytic enteritis (LPE) is challenging because clinical signs, laboratory results, diagnostic imaging findings, histology, immunohistochemistry, and clonality features may overlap.

objectivesTo evaluate possible discriminatory clinical, laboratory and ultrasonographic features to differentiate LGITL from LPE. ANIMALS: Twenty-two cats diagnosed with LGITL and 22 cats with LPE based upon histology, immunohistochemistry, and lymphoid clonality.

methodsProspective, cohort study. Cats presented with clinical signs consistent with LGITL or LPE were enrolled prospectively. All data contributing to the diagnostic evaluation was recorded.

resultsA 3-variable model (P < .001) consisting of male sex (P = .01), duration of clinical signs (P = .01), and polyphagia (P = .03) and a 2-variable model (P < .001) including a rounded jejunal lymph node (P < .001) and ultrasonographic abdominal effusion (P = .04) were both helpful to differentiate LGITL from LPE. CONCLUSIONS AND CLINICAL IMPORTANCE: Most clinical signs and laboratory results are similar between cats diagnosed with LGITL and LPE. However, male sex, a longer duration of clinical signs and polyphagia might help clinicians distinguish LGITL from LPE. On ultrasonography, a rounded jejunal lymph node, and the presence of (albeit small volume) abdominal effusion tended to be more prevalent in cats with LGITL. However, a definitive diagnosis requires comprehensive histopathologic and phenotypic assessment.

Indexed as

Cat DiseasesEnteritisLymphoma, T-CellAnimalsCatsCohort StudiesLaboratoriesMaleProspective Studiesalimentary lymphomacatchronic enteropathyfull-thickness intestinal biopsiesinflammatory bowel diseaseultrasonography

Identifiers

PMID34687072
PMCPMC8692195
OpenAlexW3207856100

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.