Evidence map›Paper›PMID 34687065›Full record

ArticleMagnetic resonance in medicine2022

Self-supervised IVIM DWI parameter estimation with a physics based forward model.

Serge Didenko Vasylechko, Simon K Warfield, Onur Afacan, Sila Kurugol

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

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  16. DIMOND: DIffusion Model OptimizatioN with Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Article
  18. Self Supervised Denoising Diffusion Probabilistic Models for Abdominal DW-MRI.Computational diffusion MRI. CDMRI (Workshop) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Serge Didenko VasylechkoComputational Radiology Laboratory, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-5691-0607
Simon K WarfieldComputational Radiology Laboratory, Boston Children's Hospital, Boston, Massachusetts, USA.
Onur AfacanComputational Radiology Laboratory, Boston Children's Hospital, Boston, Massachusetts, USA.
Sila KurugolComputational Radiology Laboratory, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · US

Funding

Improved Motion Robust MRI of ChildrenR01EB019483 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2015 to 2024
$3.9M
Acquisition of a Siemens 3T MRI for Research ImagingS10OD025111 · OD · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2018 to 2018
$2.0M
Robust quantitative MR imaging markers of response to therapy in Crohn’s DiseaseR01DK125561 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KURUGOL, SILA · 2021 to 2025
$2.0M
Machine learning algorithms to analyze large medical image datasetsR01LM013608 · NLM · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2021 to 2024
$1.5M
Machine learning for fast motion compensated quantitative abdominal DCE-MRIR21EB029627 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI KURUGOL, SILA · 2020 to 2020
$708k
Accurate quantification of kidney function with non-sedated motion-compensated pediatric MRIR21DK123569 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KURUGOL, SILA · 2020 to 2021
$487k
Boston Children's Hospital Translational Research Program Pilot Grant 2018Crohn's and Colitis Foundation of America's (CCFA) Career Development AwardNational Multiple Sclerosis Society PP-1905-34002NIBIB NIH HHS R01 EB019483NIBIB NIH HHS R21 EB029627NIDDK NIH HHS R01 DK125561NIDDK NIH HHS R21 DK123569NIH HHS 1R01DK125561-01A1NIH HHS R01EB019483NIH HHS R21DK123569NIH HHS R21EB029627NIH HHS S10 OD025111NLM NIH HHS R01 LM013608Society of Pediatric Radiology Multi-center Research Grant 2019United States-Israel Binational Science Foundation (BSF) 2019056
6 · The paper itself

Abstract

purposeTo assess the robustness and repeatability of intravoxel incoherent motion model (IVIM) parameter estimation for the diffusion-weighted MRI in the abdominal organs under the constraints of noisy diffusion signal using a novel neural network method.

methodsClinically acquired abdominal scans of Crohn's disease patients were retrospectively analyzed with regions segmented in the kidney cortex, spleen, liver, and bowel. A novel IVIM parameter fitting method based on the principle of a physics guided self-supervised convolutional neural network that does not require reference parameter estimates for training was compared to a conventional non-linear least squares (NNLS) algorithm, and a voxelwise trained artificial neural network (ANN).

resultsResults showed substantial increase in parameter robustness to the noise corrupted signal. In an intra-session repeatability experiment, the proposed method showed reduced coefficient of variation (CoV) over multiple acquisitions in comparison to conventional NLLS method and comparable performance to ANN. The use of D and f estimates from the proposed method led to the smallest misclassification error in linear discriminant analysis for characterization between normal and abnormal Crohn's disease bowel tissue. The fitting of

conclusionThe proposed method yields robust estimates of D and f IVIM parameters under the constraints of noisy diffusion signal. This indicates a potential for the use of the proposed method in conjunction with accelerated DW-MRI acquisition strategies, which would typically result in lower signal to noise ratio.

Indexed as

AlgorithmsDiffusion Magnetic Resonance ImagingHumansMotionPhysicsReproducibility of ResultsRetrospective StudiesabdominaldiffusionIVIMparameter estimationpediatricself-supervised

Identifiers

PMID34687065
PMCPMC8627432
OpenAlexW3205872023

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.