ArticleAndrologia2022
The effect of interleukin-6 level at the time of hospitalisation on erectile functions in hospitalised patients with COVID-19.
Article in Andrologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Prevalence and risk factors of erectile dysfunction in COVID-19 patients: a systematic review and meta-analysis.Journal of endocrinological investigation · 2023Pooled it
- Associations of dietary inflammatory index and composite dietary antioxidant index with erectile dysfunction and the mediating role of metabolic dysregulation: a cross-sectional analysis of NHANES 2001-2004 data.Frontiers in nutrition · 2025Article
- Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study.Journal of endocrinological investigation · 2023Article
- Effect of COVID-19 infection on the erectile function.Andrology · 2023Article
- Impact of COVID-19 on male urogenital health: Success of vaccines.Drug discovery today · 2022Review
- Advanced Molecular and Immunological Diagnostic Methods to Detect SARS-CoV-2 Infection.Microorganisms · 2022Review
- The effect of interleukin-6 level at the time of hospitalisation on erectile functions in hospitalised patients with COVID-19.Andrologia · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the relationship between erectile dysfunction (ED) and IL-6 levels in males with COVID-19. The study included 80 male patients aged 30-45 years who were hospitalised due to COVID-19. The International Index of Erectile Function (IIEF-5) questionnaire was used to assess erectile function. The IIEF-5 questionnaire was re-administered at a 3-month control visit after discharge, and the change score from baseline was recorded. The patients were divided into three groups according to the IIEF-5 score at 3 months as Group 1 (severe ED), Group 2 (moderate ED) and Group 3 (no ED), and into two groups according to IL-6 level at the time of admission as Group A (IL-6 ≤ 50 ng/ml) and Group B (IL-6 > 50 ng/ml). The change in the IIEF-5 score (p < .001) was significantly greater in Group B than in Group A. There was also significant difference in IL-6 between Group 1 and Group 2 (p = .008). The correlation analysis revealed a moderate correlation between IL-6 level and the change in IIEF-5 score and D-dimer level (r:0.529, p < .001) and a weak correlation between IL-6 level and FSH (r:0.309, p = .005). The present study suggests that elevated IL-6 levels in male patients hospitalised due to COVID-19 might be related to the risk of developing ED.
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