ArticleJournal of the Association for Research in Otolaryngology : JARO2022
Access and Polarization Electrode Impedance Changes in Electric-Acoustic Stimulation Cochlear Implant Users with Delayed Loss of Acoustic Hearing.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- A Novel Drug-Loaded Porous Parylene Electrode for Targeted Anti-Inflammatory Therapy and Hearing Preservation in Cochlear Implantation.Advanced healthcare materials · 2026Article
- Comparative spatiotemporal dynamics of access resistance, polarization impedance, and nested bipolar impedance in standard and dexamethasone-eluting electrode arrays.Hearing research · 2026Article
- Electrode impedance in cochlear implantation: determinants, dynamics, and clinical implications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Robotic-Assisted Electrode Array Insertion Improves Stability of Acoustic Hearing Thresholds.The Laryngoscope · 2026Article
- Development of zwitterionic hydrogel thin film coatings of cochlear implant electrode arrays that reduce intracochlear inflammation and electrode impedance.Hearing research · 2026Article
- Effect of early activation and perimodiolar electrodes on cochlear implant impedance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Robotic-Assisted Electrode Array Insertion Improves Rates of Hearing Preservation.The Laryngoscope · 2025Article
- Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae.Scientific reports · 2025Article
- Electrode impedance dynamics in sequential cochlear implant users: insights into cochlear immunity.Frontiers in immunology · 2025Article
- Interaural correlation of acoustic hearing preservation following sequential cochlear implantation.Frontiers in neurology · 2025Article
- Electrical Bioimpedance-Based Monitoring of Intracochlear Tissue Changes After Cochlear Implantation.Sensors (Basel, Switzerland) · 2024Article
- Delayed hearing loss after cochlear implantation: Re-evaluating the role of hair cell degeneration.Hearing research · 2024Article
- Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants.ACS applied bio materials · 2024Article
- Robotic assistance during cochlear implantation: the rationale for consistent, controlled speed of electrode array insertion.Frontiers in neurology · 2024Review
- Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation.Laryngoscope investigative otolaryngology · 2023Article
- Tissue-Engineered Cochlear Fibrosis Model Links Complex Impedance to Fibrosis Formation for Cochlear Implant Patients.Advanced healthcare materials · 2023Article
- Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings.Acta biomaterialia · 2023Article
- Cochlear implant electrode impedance subcomponents as biomarker for residual hearing.Frontiers in neurology · 2023Article
- Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics.Frontiers in pharmacology · 2023Article
- Cochlear Implant Electrode Impedance as Potential Biomarker for Residual Hearing.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Acoustic hearing can be preserved after cochlear implant (CI) surgery, allowing for combined electric-acoustic stimulation (EAS) and superior speech understanding compared to electric-only hearing. Among patients who initially retain useful acoustic hearing, 30-40 % experience a delayed hearing loss that occurs 3 or more months after CI activation. Increases in electrode impedances have been associated with delayed loss of residual acoustic hearing, suggesting a possible role of intracochlear inflammation/fibrosis as reported by Scheperle et al. (Hear Res 350:45-57, 2017) and Shaul et al. (Otol Neurotol 40(5):e518-e526, 2019). These studies measured only total impedance. Total impedance consists of a composite of access resistance, which reflects resistance of the intracochlear environment, and polarization impedance, which reflects resistive and capacitive properties of the electrode-electrolyte interface as described by Dymond (IEEE Trans Biomed Eng 23(4):274-280, 1976) and Tykocinski et al. (Otol Neurotol 26(5):948-956, 2005). To explore the role of access and polarization impedance components in loss of residual acoustic hearing, these measures were collected from Nucleus EAS CI users with stable acoustic hearing and subsequent precipitous loss of hearing. For the hearing loss group, total impedance and access resistance increased over time while polarization impedance remained stable. For the stable hearing group, total impedance and access resistance were stable while polarization impedance declined. Increased access resistance rather than polarization impedance appears to drive the increase in total impedances seen with loss of hearing. Moreover, access resistance has been correlated with intracochlear fibrosis/inflammation in animal studies as observed by Xu et al. (Hear Res 105(1-2):1-29, 1997) and Tykocinski et al. (Hear Res 159(1-2):53-68, 2001). These findings thus support intracochlear inflammation as one contributor to loss of acoustic hearing in our EAS CI population.
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Registered trials
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